Evidence map›Paper›PMID 34961663›Full record

ArticleJournal of cardiac failure2022

Frailty Measures of Patient-reported Activity and Fatigue May Predict 1-year Outcomes in Ambulatory Advanced Heart Failure: A Report From the REVIVAL Registry.

Anuradha Lala, Palak Shah, Shokoufeh Khalatbari, Matheos Yosef, Maria M Mountis, Shawn W Robinson, David E Lanfear, Jerry D Estep, Neal Jeffries, Wendy C Taddei-Peters and 6 more

Abstract read
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In one paragraph

Article in Journal of cardiac failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Anuradha LalaZena and Weil Cardiovascular Institute, Mount Sinai Hospital, Icahn School of Medicine, New York, New York; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: Anu.lala@mountsinai.org.
Palak ShahHeart Failure, Mechanical Circulatory Support and Transplant, Inova Heart and Vascular Institute, Falls Church, Virginia.
Shokoufeh KhalatbariMichigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, Michigan.
Matheos YosefMichigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, Michigan.
Maria M MountisDivision of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.
Shawn W RobinsonUniversity of Maryland, Baltimore, Maryland.
David E LanfearHeart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan.
Jerry D EstepDivision of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.
Neal JeffriesNational Heart, Lung, and Blood Institute, Bethesda, Maryland.
Wendy C Taddei-PetersNational Heart, Lung, and Blood Institute, Bethesda, Maryland.
Lynne W StevensonDepartment of Medicine, Division of Cardiology, Vanderbilt University, Nashville, Tennessee.
Blair RichardsMichigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, Michigan.
Douglas L MannDivision of Cardiovascular Medicine, Washington University School of Medicine, St. Louis, Missouri.
Donna M ManciniZena and Weil Cardiovascular Institute, Mount Sinai Hospital, Icahn School of Medicine, New York, New York; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Garrick C StewartDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Keith D AaronsonDivision of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Plasma Metabolomics and Myocardial Energetics in Heart FailureR01HL132154 · NHLBI · HENRY FORD HEALTH SYSTEM · PI LANFEAR, DAVID E, SABBAH, HANI N · 2017 to 2020
$3.1M
NCATS NIH HHS UL1 TR002240NHLBI NIH HHS HHSN268201100026CNHLBI NIH HHS R01 HL132154
6 · The paper itself

Abstract

backgroundThe Fried Frailty Phenotype predicts adverse outcomes in geriatric populations, but has not been well-studied in advanced heart failure (HF). The Registry Evaluation of Vital Information for Ventricular Assist Devices (VADs) in Ambulatory Life (REVIVAL) study prospectively collected frailty measures in patients with advanced HF to determine relevant assessments and their impact on clinical outcomes. METHODS AND

resultsHF-Fried Frailty was defined by 5 baseline components (1 point each): (1) weakness: hand grip strength less than 25% of body weight; (2) slowness based on time to walk 15 feet; (3) weight loss of more than 10 lbs in the past year; (4) inactivity; and (5) exhaustion, both assessed by the Kansas City Cardiomyopathy Questionnaire. A score of 0 or 1 was deemed nonfrail, 2 prefrail, and 3 or greater was considered frail. The primary composite outcome was durable mechanical circulatory support implantation, cardiac transplant or death at 1 year. Event-free survival for each group was determined by the Kaplan-Meier method and the hazard of prefrailty and frailty were compared with nonfrailty with proportional hazards modeling. Among 345 patients with all 5 frailty domains assessed, frailty was present in 17%, prefrailty in 40%, and 43% were nonfrail, with 67% (n = 232) meeting the criteria based on inactivity and 54% (n = 186) for exhaustion. Frail patients had an increased risk of the primary composite outcome (unadjusted hazard ratio [HR] 2.82, 95% confidence interval [CI] 1.52-5.24; adjusted HR 3.41, 95% CI 1.79-6.52), as did prefrail patients (unadjusted HR 1.97, 95% CI 1.14-3.41; adjusted HR 2.11, 95% CI 1.21-3.66) compared with nonfrail patients, however, the predictive value of HF-Fried Frailty criteria was modest (Harrel's C-statistic of 0.603, P = .004).

conclusionsThe HF-Fried Frailty criteria had only modest predictive power in identifying ambulatory patients with advanced HF at high risk for durable mechanical circulatory support, transplant, or death within 1 year, driven primarily by assessments of inactivity and exhaustion. Focus on these patient-reported measures may better inform clinical trajectories in this population.

Indexed as

FrailtyHeart FailureAgedFatigueFrail ElderlyHand StrengthHumansPatient Reported Outcome MeasuresRegistriesfrailtyHeart failureheart transplantleft ventricular assist deviceoutcomes

Identifiers

PMID34961663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.