ArticleTropical medicine and health2021
Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal.
Article in Tropical medicine and health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Combating Foodborne MRSA: Identification and Silver Nanoparticle-Based Antibacterial Strategies with Antibiotic Synergy and Resistance Evolution Assessment.Microorganisms · 2025Article
- Epidemiology and risk factors of Methicillin-ResistantSaudi medical journal · 2025Article
- Investigating the production and synergistic antibacterial activity of bacteriocin-like substance fromHeliyon · 2025Article
- Clindamycin-resistant among Staphylococcus aureus: Investigation into phenotypic and genotypic profiles.PloS one · 2025Article
- Methicillin and inducible clindamycin resistance in clinicalFrontiers in microbiology · 2025Article
- Nasal Carriage of Methicillin-ResistantInterdisciplinary perspectives on infectious diseases · 2025Article
- GENETIC DETERMINANTS OF ANTIBIOTIC RESISTANCE AND VIRULENCE INAfrican journal of infectious diseases · 2025Article
- Recent development and fighting strategies for lincosamide antibiotic resistance.Clinical microbiology reviews · 2024Review
- Bridging drug discovery through hierarchical subtractive genomics against asd, trpG, and secY of pneumonia causing MDR Staphylococcus aureus.Molecular genetics and genomics : MGG · 2024Article
- Multidrug-Resistant Commensal and Infection-CausingVeterinary sciences · 2024Article
- Non-traditional small companion mammals in Spain as reservoirs of antimicrobial-resistantFrontiers in veterinary science · 2024Article
- Antimicrobial Resistance Patterns of Pathogens Isolated from Patients with Wound Infection at a Teaching Hospital in Vietnam.Infection and drug resistance · 2024Article
- Detection of Biofilm Production and Antibiotic Susceptibility Pattern among Clinically IsolatedJournal of pathogens · 2024Article
- Inducible clindamycin resistance among clinical Gram-positive cocci in a tertiary hospital in Niger Republic.Access microbiology · 2024Article
- Effect of Quorum Sensing Molecule Farnesol on Mixed Biofilms ofAntibiotics (Basel, Switzerland) · 2023Article
- Heterogeneous Vancomycin IntermediateInfection and drug resistance · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcus aureus is a global public health issue in both community and hospital settings. Management of methicillin-resistant S. aureus (MRSA) infections are tough owing to its resistance to many antibiotics. Macrolide-lincosamide-streptogramin B (MLSB) antibiotics are commonly used for the management of MRSA. This study was aimed to determine the occurrence of inducible clindamycin- and methicillin-resistant S. aureus at a tertiary care hospital in Kathmandu, Nepal.
methodsA total of 1027 clinical samples were processed following standard laboratory procedures and antibiotic susceptibility testing of S. aureus was performed by disc diffusion method. MRSA isolates were detected phenotypically using cefoxitin disc, and inducible clindamycin resistance was detected phenotypically using the D-zone test.
resultsOf 1027 samples, 321 (31.2%) were culture positive, of which 38 (11.8%) were S. aureus. All S. aureus isolates were susceptible to vancomycin, and 25 (67%) of S. aureus isolates were multidrug-resistant. Similarly, 15 (39.5%) of S. aureus were MRSA and 14 (36.5%) were inducible clindamycin-resistant phenotypes.
conclusionInducible clindamycin and methicillin resistance were common in S. aureus. This emphasizes that the methicillin resistance test and the D-zone test should be incorporated into the routine antibiotic susceptibility testing in hospital settings.
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