ArticleJournal of cardiothoracic surgery2021
Surgical techniques for aortic valve xenotransplantation.
Article in Journal of cardiothoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Biogenic polymer-based heart valve for congenital cardiac surgery.JTCVS open · 2026Article
- Porcine xenotransplantation in the clinical era: converging advances and unresolved barriers on the path to clinical translation - a narrative review.Frontiers in immunology · 2026Review
- Bioengineered heart valves for personalized therapy: advances in manufacturing and clinical challenges.Frontiers in bioengineering and biotechnology · 2025Review
- Surgical Protocol for Partial Heart Transplantation in Growing Piglets.World journal for pediatric & congenital heart surgery · 2024Article
- Animal models for partial heart transplantation.Pediatric transplantation · 2024Review
- Partial heart transplantation: Growing heart valve implants for children.Artificial organs · 2024Review
- Characterization of Green Fluorescent Protein in Heart Valves of a Transgenic Swine Model for Partial Heart Transplant Research.Journal of cardiovascular development and disease · 2023Article
- Growing Heart Valve Implants for Children.Journal of cardiovascular development and disease · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHeart valve replacement in neonates and infants is one of the remaining unsolved problems in cardiac surgery because conventional valve prostheses do not grow with the children. Similarly, heart valve replacement in children and young adults with contraindications to anticoagulation remains an unsolved problem because mechanical valves are thrombogenic and bioprosthetic valves are prone to early degeneration. Therefore, there is an urgent clinical need for growing heart valve replacements that are durable without the need for anticoagulation.
methodsA human cadaver model was used to develop surgical techniques for aortic valve xenotransplantation.
resultsAortic valve xenotransplantation is technically feasible. Subcoronary implantation of the valve avoids the need for a root replacement.
conclusionAortic valve xenotransplantation is promising because the development of GTKO.hCD46.hTBM transgenic pigs has brought xenotransplantation within clinical reach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.