Evidence map›Paper›PMID 34961502›Full record

ArticleBMC surgery2021

Self-administered succus entericus reinfusion before ileostomy closure improves short-term outcomes.

Zhen Liu, Liang Fang, Liang Lv, Zhaojian Niu, Litao Hou, Dong Chen, Yanbing Zhou, Dong Guo

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07640113 (The STIMIC Trial), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07640113 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The STIMIC Trial: A Multicenter Randomized Control Trial Evaluating the Impact of Ambulatory Physiological Stimulation of the Efferent Limb Prior to Ileostomy Closure on Colorectal Microbiota Composition and Histopathological Findings

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2026 to 2028Enrolled90ConditionsIleostomy Stoma, Stoma Stimulation, Microbiome AnalysisArmsSerum stimulation, Physiological stimulation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Use of parenteral nutrition in the management of enterocutaneous fistula.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhen LiuDepartment of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Liang FangDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Liang LvDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Rd, Qingdao, 266000, Shandong, China.
Zhaojian NiuDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Rd, Qingdao, 266000, Shandong, China.
Litao HouDepartment of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Dong ChenDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Rd, Qingdao, 266000, Shandong, China.
Yanbing ZhouDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Rd, Qingdao, 266000, Shandong, China.
Dong GuoDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Rd, Qingdao, 266000, Shandong, China. guo.nju@hotmail.com.
Affiliated Hospital of Qingdao University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aims to assess whether reinfusion of succus entericus prior to ileostomy closure can decrease postoperative length of stay and ameliorate low anterior resection score.

methodsThis study is a retrospective analysis based on prospectively collected data. Patients were screened from May 2016 to November 2019. A total of 30 patients who underwent reinfusion with succus entericus (SER) were enrolled in the SER group and 42 patients without SER were enrolled in the non-SER group.

resultsThere was no significant difference in the incidence of postoperative ileus between succus entericus reinfusion (SER) group and the control group. Time to first passage of flatus or stool after surgery in the SER group (27.9 ± 6.02 h) is significantly shorter than the control group (32.3 ± 6.26, hours p = 0.004). Compared with the control group (5.52 (4.0-7.0) days), postoperative length of stay in the SER group was 4.90 (3.0-7.0)days (p = 0.009). As for low anterior resection score(LARS), the SER group had a lower score 1 week after discharge than the control group (p = 0.034). However, 1 month after discharge, the LARS in the two groups had no significant difference.

conclusionsSelf-administered succus entericus reinfusion is a feasible prehabilitation management for outpatients and can improve better outcomes. Compared with non-reinfusion group, succus enterius reinfusion group displays significantly shorter time for gastrointestinal function recovery and postoperative hospital stay without increasing complication, and it can bring better quality of life in a short term.

Indexed as

IleostomyRectal NeoplasmsHumansIntestinal SecretionsIntestine, SmallPostoperative ComplicationsQuality of LifeRetrospective StudiesClinical outcomesQuality of lifeRectal cancer ileostomy closureSuccus entericus reinfusion

Identifiers

PMID34961502
PMCPMC8713408
OpenAlexW4226143691

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.