ReviewPlants (Basel, Switzerland)2021
Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors.
Review in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Elicitor-Mediated Enhancement of Secondary-Metabolite Biosynthesis inPlants (Basel, Switzerland) · 2026Review
- PlantInternational journal of molecular sciences · 2026Review
- Industrial Bioreactor Technologies for Modern Biomanufacturing: Recent Applications in Microbial, Mammalian, and Plant-Based Systems.Molecular biotechnology · 2026Review
- Bioreactor Technology for Medicinal Plant In Vitro Cultures: Systems, Applications, and Future Perspectives.Biology · 2026Review
- Extracellular vesicles as therapeutic agents for retinal ganglion cell degeneration: current challenges and future prospects.International ophthalmology · 2026Review
- Advances in Functional Genomics and Biotechnology for Enhancing Therapeutic Potential of Medicinal Plants.International journal of molecular sciences · 2026Review
- In vitro bioactive metabolite production and plant regeneration of medicinal plant Ligusticum chuanxiong Hort.BMC plant biology · 2026Article
- Transcriptome-Based Analysis of Core Hub Genes Related to Cell Adhesion in Vero Cells.BioMed research international · 2026Article
- Effect of activated charcoal and subculture rates on a two-phase culture strategy involving biomass accumulation followed by phenolic production in date palm cell suspension cultures.BMC plant biology · 2025Article
- Cascade Oxygen Control Enhances Growth ofPlants (Basel, Switzerland) · 2025Article
- Metabolic Engineering of Terpenoid Biosynthesis in Medicinal Plants: From Genomic Insights to Biotechnological Applications.Current issues in molecular biology · 2025Review
- The Occurrence, Uses, Biosynthetic Pathway, and Biotechnological Production of Plumbagin, a Potent Antitumor Naphthoquinone.Molecules (Basel, Switzerland) · 2025Review
- Characterizing the effect of impeller design in plant cell fermentations using CFD modeling.Scientific reports · 2025Article
- Huperzine A Production and Acetylcholinesterase Inhibition byPharmaceuticals (Basel, Switzerland) · 2025Article
- Impact ofBiotech (Basel (Switzerland)) · 2025Article
- Model-based fed-batch cultivation ofFrontiers in bioengineering and biotechnology · 2025Article
- Establishment of embryogenic Pinus thunbergii Parl. suspension cultures: growth parameters, dynamic analysis, and plant regenerative capacities.BMC plant biology · 2024Article
- Phytochemical Profiles and Cytotoxic Activity ofPlants (Basel, Switzerland) · 2024Article
- Bioreactor Systems for Plant Cell Cultivation at the Institute of Plant Physiology of the Russian Academy of Sciences: 50 Years of Technology Evolution from Laboratory to Industrial Implications.Plants (Basel, Switzerland) · 2024Review
- Metabolome and transcriptome integration explored the mechanism of browning inFrontiers in plant science · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to meet the increasing demand for bioactive compounds for the treatment and prevention of degenerative diseases is nowadays considered an engineering challenge due to the large number of operational factors that need to be considered during their design and scale-up. The plant cell suspension culture (CSC) has presented numerous benefits over other technologies, such as the conventional whole-plant extraction, not only for avoiding the overexploitation of plant species, but also for achieving better yields and having excellent scaling-up attributes. The selection of the bioreactor configuration depends on intrinsic cell culture properties and engineering considerations related to the effect of operating conditions on thermodynamics, kinetics, and transport phenomena, which together are essential for accomplishing the large-scale production of PDSM. To this end, this review, firstly, provides a comprehensive appraisement of PDSM, essentially those with demonstrated importance and utilization in pharmaceutical industries. Then, special attention is given to PDSM obtained out of CSC. Finally, engineering aspects related to the bioreactor configuration for CSC stating the effect of the operating conditions on kinetics and transport phenomena and, hence, on the cell viability and production of PDSM are presented accordingly. The engineering analysis of the reviewed bioreactor configurations for CSC will pave the way for future research focused on their scaling up, to produce high value-added PDSM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.