Evidence map›Paper›PMID 34960929›Full record

ArticlePolymers2021

Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair.

Ana S Neto, Patrícia Pereira, Ana C Fonseca, Carla Dias, Mariana C Almeida, Inês Barros, Catarina O Miranda, Luís P de Almeida, Paula V Morais, Jorge F J Coelho and 1 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polymers · 2023
    Article
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  6. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ana S NetoDepartment of Materials and Ceramic Engineering/CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
Patrícia PereiraDepartment of Chemical Engineering, CEMMPRE, University of Coimbra, 3030-790 Coimbra, Portugal.
Ana C FonsecaDepartment of Chemical Engineering, CEMMPRE, University of Coimbra, 3030-790 Coimbra, Portugal.
Carla DiasDepartment of Life Sciences, CEMMPRE, University of Coimbra, 3001-401 Coimbra, Portugal.
Mariana C AlmeidaDepartment of Life Sciences, CEMMPRE, University of Coimbra, 3001-401 Coimbra, Portugal.
Inês BarrosCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0002-3893-6416
Catarina O MirandaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Luís P de AlmeidaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0001-5831-3307
Paula V MoraisDepartment of Life Sciences, CEMMPRE, University of Coimbra, 3001-401 Coimbra, Portugal.ORCID 0000-0002-1939-6389
Jorge F J CoelhoDepartment of Chemical Engineering, CEMMPRE, University of Coimbra, 3030-790 Coimbra, Portugal.
José M F FerreiraDepartment of Materials and Ceramic Engineering/CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-7520-2809
University of Coimbra · PTUniversity of Aveiro · PTInstituto Pedro Nunes · PT

Funding

COMPETE 2020 CENTRO-01-0145-FEDER-022095COMPETE2020 CENTRO-01-0145-FEDER-000008Fundação para a Ciência e Tecnologia SFRH/BD/148877/2019Fundação para a Ciência e Tecnologia UIBD/00511/2020Fundação para a Ciência e Tecnologia UIDB/00285/2020Fundação para a Ciência e Tecnologia UIDB/04539/2020Fundação para a Ciência e Tecnologia UID/CTM/50011/2019
6 · The paper itself

Abstract

The present study deals with the development of multifunctional biphasic calcium phosphate (BCP) scaffolds coated with biopolymers-poly(ε-caprolactone) (PCL) or poly(ester urea) (PEU)-loaded with an antibiotic drug, Rifampicin (RFP). The amounts of RFP incorporated into the PCL and PEU-coated scaffolds were 0.55 ± 0.04 and 0.45 ± 0.02 wt%, respectively. The in vitro drug release profiles in phosphate buffered saline over 6 days were characterized by a burst release within the first 8h, followed by a sustained release. The Korsmeyer-Peppas model showed that RFP release was controlled by polymer-specific non-Fickian diffusion. A faster burst release (67.33 ± 1.48%) was observed for the PCL-coated samples, in comparison to that measured (47.23 ± 0.31%) for the PEU-coated samples. The growth inhibitory activity against

Indexed as

biphasic calcium phosphatecuttlefish bonedrug delivery systempolymeric coatingsrifampicin

Identifiers

PMID34960929
PMCPMC8705097
OpenAlexW4200620906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.