Evidence map›Paper›PMID 34960820›Full record

ArticleViruses2021

Protection against Congenital CMV Infection Conferred by MVA-Vectored Subunit Vaccines Extends to a Second Pregnancy after Maternal Challenge with a Heterologous, Novel Strain Variant.

Claudia Fernández-Alarcón, Grace Buchholz, Heidi Contreras, Felix Wussow, Jenny Nguyen, Don J Diamond, Mark R Schleiss

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Claudia Fernández-AlarcónDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0003-2210-7792
Grace BuchholzDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Heidi ContrerasDepartment of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0003-4476-9156
Felix WussowDepartment of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA 91010, USA.
Jenny NguyenDepartment of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA 91010, USA.
Don J DiamondDepartment of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA 91010, USA.
Mark R SchleissDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0002-2108-9433
City Of Hope National Medical Center · USUniversity of Minnesota Medical Center · US

Funding

Optimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus InfectionR01HD098866 · NICHD · UNIVERSITY OF MINNESOTA · PI Craig John Bierle, Michael A McVoy · 2019 to 2026
$3.9M
Optimized Vaccines Against Congenital Infection and Maternal Reinfection with CMVR01HD079918 · NICHD · UNIVERSITY OF MINNESOTA · PI SCHLEISS, MARK R. · 2015 to 2019
$1.6M
Rapid Diagnostic for Human Cytomegalovirus (HCMV) Serological Status75N93019C00030 · NIAID · NANOCOMPOSIX, INC. · PI BALDWIN, RICHARD · 2019 to 2019
$1.5M
Preclinical Evaluation of a Novel rLCMV Single-Cycle Vectored CMV VaccineR56AI114013 · NIAID · UNIVERSITY OF MINNESOTA · PI SCHLEISS, MARK R. · 2015 to 2015
$342k
National Institute of Allergy and Infectious Diseases 114013National Institute of Health P50CA107399National Institute of Health U19AI128913NIAID NIH HHS 75N93019C00030NICHD NIH HHS R01 HD079918NICHD NIH HHS R01 HD098866Wellcome Trust 082273
6 · The paper itself

Abstract

Maternal reinfection of immune women with novel human cytomegalovirus (HCMV) strains acquired during pregnancy can result in symptomatic congenital CMV (cCMV) infection. Novel animal model strategies are needed to explore vaccine-mediated protections against maternal reinfection. To investigate this in the guinea pig cytomegalovirus (GPCMV) model, a strictly in vivo-passaged workpool of a novel strain, the CIDMTR strain (dose, 1 × 10

Indexed as

VaccinationAnimalsCells, CulturedCytomegalovirus InfectionsCytomegalovirus VaccinesFemaleGenetic VectorsGuinea PigsInfectious Disease Transmission, VerticalPregnancyVaccines, SubunitVaccinia virusViral LoadCytomegalovirus VaccinesVaccines, SubunitCIDTMR strainCMV reinfectionCMV vaccinecongenital CMVgOguinea pigpentameric complexTAMYC

Identifiers

PMID34960820
PMCPMC8703303
OpenAlexW4200308004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.