Evidence map›Paper›PMID 34960800›Full record

ArticleViruses2021

Cryo-EM Structures of Two Bacteriophage Portal Proteins Provide Insights for Antimicrobial Phage Engineering.

Abid Javed, Hugo Villanueva, Shadikejiang Shataer, Sara Vasciaveo, Renos Savva, Elena V Orlova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Abid JavedDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.ORCID 0000-0002-5829-6057
Hugo VillanuevaDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.
Shadikejiang ShataerDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.
Sara VasciaveoDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.
Renos SavvaDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.ORCID 0000-0001-7375-2340
Elena V OrlovaDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.ORCID 0000-0003-3371-415X
Institute of Structural and Molecular Biology · GBStevenage Bioscience Catalyst · GBUniversity of Leeds · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M009513Biotechnology and Biological Sciences Research Council BB/R002622/1Wellcome Trust 202679/Z/16/ZWellcome Trust 206166/Z/17/Z
6 · The paper itself

Abstract

Widespread antibiotic resistance has returned attention to bacteriophages as a means of managing bacterial pathogenesis. Synthetic biology approaches to engineer phages have demonstrated genomic editing to broaden natural host ranges, or to optimise microbicidal action. Gram positive pathogens cause serious pastoral animal and human infections that are especially lethal in newborns. Such pathogens are targeted by the obligate lytic phages of the

Indexed as

Genetic EngineeringBacillus pumilusBacteriophagesCapsid ProteinsCaudoviralesClostridium perfringensCryoelectron MicroscopyHost SpecificityPhylogenyProtein DomainsProtein EngineeringSynthetic BiologyCapsid Proteinsbacteriophageclip domaincryo electron microscopyGA1phiCPV4portal proteinstructural analysis

Identifiers

PMID34960800
PMCPMC8703570
OpenAlexW4200417407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.