Evidence map›Paper›PMID 34960797›Full record

ArticleViruses2021

Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus.

Elisabeth Le Glass, Van Thuan Hoang, Céline Boschi, Laetitia Ninove, Christine Zandotti, Aurélie Boutin, Valérie Bremond, Grégory Dubourg, Stéphane Ranque, Jean-Christophe Lagier and 5 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
  2. Article
  3. Viral co-infection with SARS-CoV-2 in hospitalized Peruvian patients during 2020-2021.Revista peruana de medicina experimental y salud publica · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Leptospirosis and coinfections leading to fatal multiple organ and system failure.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Elisabeth Le GlassInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Van Thuan HoangThai Binh University of Medicine and Pharmacy, Thai Binh 410000, Vietnam.ORCID 0000-0003-1369-8615
Céline BoschiInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Laetitia NinoveInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Christine ZandottiInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Aurélie BoutinAssistance-Publique-Hôpitaux de Marseille, Service des Urgences Pédiatriques, CHU Timone, 264 rue Saint-Pierre, 13005 Marseille, France.
Valérie BremondAssistance-Publique-Hôpitaux de Marseille, Service des Urgences Pédiatriques, CHU Timone, 264 rue Saint-Pierre, 13005 Marseille, France.
Grégory DubourgInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Stéphane RanqueInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Jean-Christophe LagierInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Matthieu MillionInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Pierre-Edouard FournierInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Michel DrancourtInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Philippe GautretInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
Philippe ColsonInstitut Hospitalo-Universitaire Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.ORCID 0000-0001-6285-0308
Aix-Marseille Université · FRAssistance Publique Hôpitaux de Marseille · FRMéditerranée Infection Foundation · FRInserm · FRThai Binh University of Medicine and Pharmacy · VN

Funding

Agence Nationale de la Recherche Méditerranée-Infection 10-IAHU-03Région Provence Alpes Côte d'Azur and Europe FEDER PA 0000320 PRIMMI
6 · The paper itself

Abstract

backgroundWe aimed to compare the clinical severity in patients who were coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and rhinovirus or monoinfected with a single one of these viruses.

methodsThe study period ranged from 1 March 2020 to 28 February 2021 (one year). SARS-CoV-2 and other respiratory viruses were identified by real-time reverse-transcription-PCR as part of the routine work at Marseille University hospitals. Bacterial and fungal infections were detected by standard methods. Clinical data were retrospectively collected from medical files. This study was approved by the ethical committee of our institute.

resultsA total of 6034/15,157 (40%) tested patients were positive for at least one respiratory virus. Ninety-three (4.3%) SARS-CoV-2-infected patients were coinfected with another respiratory virus, with rhinovirus being the most frequent (62/93, 67%). Patients coinfected with SARS-CoV-2 and rhinovirus were significantly more likely to report a cough than those with SARS-CoV-2 monoinfection (62% vs. 31%;

conclusionsA close surveillance and investigation of the co-incidence and interactions of SARS-CoV-2 and other respiratory viruses is needed. The possible higher risk of increased clinical severity in SARS-CoV-2-positive patients coinfected with rhinovirus warrants further large scale studies.

Indexed as

AdolescentAdultAgedChildCoinfectionCOVID-19FemaleHumansIncidenceMaleMiddle AgedPicornaviridae InfectionsReal-Time Polymerase Chain ReactionRespiratory Tract InfectionsRetrospective StudiesRhinoviruscoinfectionCOVID-19rhinovirusSARS-CoV-2severity

Identifiers

PMID34960797
PMCPMC8709236
OpenAlexW4200345355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.