ArticleViruses2021
sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.
Open access · goldAbstract read
In one paragraph
Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Endotheliopathy in Acute COVID-19 and Long COVID.International journal of molecular sciences · 2023Pooled it
- COVID-19 vaccination shifts neutrophils toward a mixed activated and regulatory phenotype in patients with severe disease.Molecular biology reports · 2026Observational
- Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool.The Journal of infectious diseases · 2026Article
- Biological Plausibility Between Long-COVID and Periodontal Disease Development or Progression.Biomedicines · 2025Review
- Differential immune profiles in elderly patients with non-severe versus severe SARS-CoV-2 omicron variant infection: dysregulation of antibody responses and B-cell subsets.Immunity & ageing : I & A · 2025Article
- Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in Inflammation and Disease: Mechanisms, Therapeutic Potential, and Future Directions.International journal of molecular sciences · 2025Review
- Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) predicts mortality in patients with febrile illness in southern Mozambique.Communications medicine · 2025Article
- Article
- Pilot Screening of TREM1 Inhibitors in Cell-Based Reporter Assays Reflecting TREM1/DAP12 Receptor Assembly and Functionality.ACS chemical neuroscience · 2025Article
- AIDET communication combined with alternating prone ventilation for HIF-1α, sTREM-1 and hs-CRP in awake elderly patients with severe pneumonia.Frontiers in medicine · 2025Article
- Exploratory study of the effect of DHA supplementation on blood fatty acids and inflammatory markers in children with MIS-C.Frontiers in nutrition · 2025Article
- sTREM-1: A Biomarker of Mortality in Severe Malaria Impacted by Acute Kidney Injury.The Journal of infectious diseases · 2024Article
- Changes in the innate immune response to SARS-CoV-2 with advancing age in humans.Immunity & ageing : I & A · 2024Article
- Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies.Critical care (London, England) · 2024Review
- Prognostic performance of early immune and endothelial activation markers in mild-to-moderate COVID-19 outpatients: a nested case-control study.Frontiers in immunology · 2024Article
- sTREM-1 as a Predictive Biomarker for Disease Severity and Prognosis in COVID-19 Patients.Journal of inflammation research · 2024Article
- Active Matrix Metalloproteinase-8 (aMMP-8) Versus Total MMP-8 in Periodontal and Peri-Implant Disease Point-of-Care Diagnostics.Biomedicines · 2023Article
- Validation of sTREM-1 and IL-6 based algorithms for outcome prediction of COVID-19.BMC infectious diseases · 2023Observational
- Soluble TREM-1 plasma concentration predicts poor outcome in COVID-19 patients.Intensive care medicine experimental · 2023Article
- Age-related changes in plasma biomarkers and their association with mortality in COVID-19.The European respiratory journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 6 institutions in 2 countries.
Pedro V da Silva-NetoDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Jonatan C S de CarvalhoDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Vinícius E PimentelDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0003-3411-1545
Malena M PérezDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Diana M ToroDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Thais F C Fraga-SilvaDepartamento de Bioquímica e Imunologia. Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil.ORCID 0000-0002-2053-8938
Carlos A FuzoDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0003-3198-9969
Camilla N S OliveiraDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Lilian C RodriguesDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Jamille G M ArgoloEscola de Enfermagem de Ribeirão Preto-EERP, Universidade de São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.
Ingryd Carmona-GarciaEscola de Enfermagem de Ribeirão Preto-EERP, Universidade de São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.
Nicola T NetoEscola de Enfermagem de Ribeirão Preto-EERP, Universidade de São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.
Camila O S SouzaDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-6922-5270
Talita M FernandesEscola de Enfermagem de Ribeirão Preto-EERP, Universidade de São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.
Victor A F BastosDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Augusto M DegiovaniHospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil.
Leticia F ConstantHospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil.
Fátima M OstiniHospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil.
Marley R FeitosaDepartamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo (USP), Ribeirão Preto 14048-900, SP, Brazil.
Rogerio S ParraDepartamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo (USP), Ribeirão Preto 14048-900, SP, Brazil.ORCID 0000-0002-5566-9284
Fernando C VilarDepartamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo (USP), Ribeirão Preto 14049-900, SP, Brazil.
Gilberto G GasparDepartamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo (USP), Ribeirão Preto 14049-900, SP, Brazil.
José J R da RochaDepartamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo (USP), Ribeirão Preto 14048-900, SP, Brazil.
Omar FeresDepartamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo (USP), Ribeirão Preto 14048-900, SP, Brazil.
Fabiani G FrantzDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Raquel F GerlachDepartamento de Morfologia, Fisiologia e Patologia básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto 14040-904, SP, Brazil.
Sandra R MaruyamaCentro de Ciências Biológicas e da Saúde, Departamento de Genética e Evolução, Universidade Federal de São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil.
Elisa M S RussoDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-9274-7915
Angelina L VianaEscola de Enfermagem de Ribeirão Preto-EERP, Universidade de São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.ORCID 0000-0002-4913-0370
Ana P M FernandesEscola de Enfermagem de Ribeirão Preto-EERP, Universidade de São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.
Isabel K F M SantosDepartamento de Bioquímica e Imunologia. Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil.
Vânia L D BonatoDepartamento de Bioquímica e Imunologia. Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil.ORCID 0000-0003-4189-2685
Antonio L BoechatPrograma de Pós-Graduação em Imunologia Básica e Aplicada-PPGIBA, Instituto de Ciências Biológicas, Universidade Federal do Amazonas-UFAM, Manaus 69080-900, AM, Brazil.ORCID 0000-0001-5597-7343
Adriana MalheiroPrograma de Pós-Graduação em Imunologia Básica e Aplicada-PPGIBA, Instituto de Ciências Biológicas, Universidade Federal do Amazonas-UFAM, Manaus 69080-900, AM, Brazil.
Ruxana T SadikotDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Marcelo Dias-BaruffiDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Cristina R B CardosoDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Lúcia H FaccioliDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-4999-8305
Carlos A SorgiPrograma de Pós-Graduação em Imunologia Básica e Aplicada-PPGIBA, Instituto de Ciências Biológicas, Universidade Federal do Amazonas-UFAM, Manaus 69080-900, AM, Brazil.
On Behalf Of The Imunocovid Study Group
Universidade de Ribeirão Preto · BRUniversidade de São Paulo · BRCentro de Reprodução Humana Prof. Franco Junior · BRUniversidade Federal do Amazonas · BRUniversidade Federal de São Carlos · BRUniversity of Nebraska Medical Center · US
Funding
BLRD VA I01 BX001786
Abstract
Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1) as a biomarker of the severity and mortality of COVID-19. Based on their clinical scores, we enrolled COVID-19 positive patients (
Indexed as
Severity of Illness IndexAdolescentAdultAgedAged, 80 and overBiomarkersBrazilCOVID-19FemaleHumansInflammationInterleukin-10Interleukin-6Interleukin-8Leukocyte CountLeukocytesBiomarkersInterleukin-10Interleukin-6Interleukin-8Matrix Metalloproteinase 8Triggering Receptor Expressed on Myeloid Cells-1biomarkerCOVID-19inflammationMMP-8sTREM-1
Identifiers
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