Evidence map›Paper›PMID 34960786›Full record

ArticleViruses2021

Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.

Guillaume Favre, Sara Mazzetti, Carole Gengler, Claire Bertelli, Juliane Schneider, Bernard Laubscher, Romina Capoccia, Fatemeh Pakniyat, Inès Ben Jazia, Béatrice Eggel-Hort and 5 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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  4. Perinatal arterial ischemic stroke: how informative is the placenta?Virchows Archiv : an international journal of pathology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Guillaume FavreMaterno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0001-6181-3126
Sara MazzettiClinic of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Carole GenglerDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Claire BertelliInstitute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Juliane SchneiderClinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0001-6849-6178
Bernard LaubscherClinic of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Romina CapocciaDepartment of Obstetrics and Gynecology, Réseau Hospitalier Neuchâtelois, 2000 Neuchatel, Switzerland.
Fatemeh PakniyatDepartment of Obstetrics and Gynecology, Réseau Hospitalier Neuchâtelois, 2000 Neuchatel, Switzerland.
Inès Ben JaziaDepartment of Obstetrics and Gynecology, Réseau Hospitalier Neuchâtelois, 2000 Neuchatel, Switzerland.
Béatrice Eggel-HortDepartment of Obstetrics and Gynecology, Hôpital du Valais-Centre Hospitalier du Valais Romand-Site de Sion, 1951 Sion, Switzerland.
Laurence de LevalDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Léo PomarMaterno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-3021-8129
Gilbert GreubInstitute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0001-9529-3317
David BaudMaterno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0001-9914-6496
Eric GiannoniClinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0003-0897-6529
University of Lausanne · CHHospital Neuchâtel · CHHES-SO University of Applied Sciences and Arts Western Switzerland · CHHôpital du Valais · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.

Indexed as

AdultBrain InjuriesCesarean SectionCOVID-19FemaleFetal MovementHumansInfant, NewbornInfant, PrematureInfectious Disease Transmission, VerticalLeukomalacia, PeriventricularPlacentaPregnancyPregnancy Complications, InfectiousSARS-CoV-2brain injuryCOVID-19fetal movementsMRIneurosonographyperinatalplacentalSARS-CoV-2

Identifiers

PMID34960786
PMCPMC8706116
OpenAlexW4200062123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.