Evidence map›Paper›PMID 34960684›Full record

ArticleViruses2021

COVID-19 Modulates Inflammatory and Renal Markers That May Predict Hospital Outcomes among African American Males.

Wendy Fonseca, Nobuhiro Asai, Kazuma Yagi, Carrie-Anne Malinczak, Gina Savickas, Christine C Johnson, Shannon Murray, Edward M Zoratti, Nicholas W Lukacs, Jia Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. The Role of Osteopontin in Respiratory Health and Disease.Journal of personalized medicine · 2023
    Review
  8. Article
  9. The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wendy FonsecaDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8982-4633
Nobuhiro AsaiDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Kazuma YagiDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Carrie-Anne MalinczakDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Gina SavickasTranslational and Clinical Research Center, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.
Christine C JohnsonDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA.
Shannon MurrayTranslational and Clinical Research Center, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.
Edward M ZorattiDivision of Allergy and Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.
Nicholas W LukacsDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Jia LiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA.
Charles F Schuler IvMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5656-7418

Funding

Lung Immunopathology Training Stipend SupplementT32HL007517 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKACS, NICHOLAS W · 1985 to 2022
$6.1M
Henry Ford Health System Institutional FundsMary H. Weiser Food Allergy Center Gift FundsNHLBI NIH HHS T32 HL007517
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAfrican Americans and males have elevated risks of infection, hospitalization, and death from SARS-CoV-2 in comparison with other populations. We report immune responses and renal injury markers in African American male patients hospitalized for COVID-19.

methodsThis was a single-center, retrospective study of 56 COVID-19 infected hospitalized African American males 50+ years of age selected from among non-intensive care unit (ICU) and ICU status patients. Demographics, hospitalization-related variables, and medical history were collected from electronic medical records. Plasma samples collected close to admission (≤2 days) were evaluated for cytokines and renal markers; results were compared to a control group (

resultsAmong COVID-19 patients, eight (14.2%) suffered in-hospital mortality; seven (23.3%) in the ICU and one (3.8%) among non-ICU patients. Interleukin (IL)-18 and IL-33 were elevated at admission in COVID-19 patients in comparison with controls. IL-6, IL-18, MCP-1/CCL2, MIP-1α/CCL3, IL-33, GST, and osteopontin were upregulated at admission in ICU patients in comparison with controls. In addition to clinical factors, MCP-1 and GST may provide incremental value for risk prediction of COVID-19 in-hospital mortality.

conclusionsQualitatively similar inflammatory responses were observed in comparison to other populations reported in the literature, suggesting non-immunologic factors may account for outcome differences. Further, we provide initial evidence for cytokine and renal toxicity markers as prognostic factors for COVID-19 in-hospital mortality among African American males.

Indexed as

HospitalsAgedBiomarkersBlack or African AmericanCOVID-19CytokinesHospitalizationHospital MortalityHumansIntensive Care UnitsKidneyMaleMichiganMiddle AgedRetrospective StudiesSARS-CoV-2BiomarkersCytokinesCOVID-19cytokinesrenal toxicitySARS-CoV-2

Identifiers

PMID34960684
PMCPMC8708877

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.