Evidence map›Paper›PMID 34960607›Full record

ArticleViruses2021

Gammaherpesvirus Infections in Cattle in Europe.

Giuliana Rosato, Andres Ruiz Subira, Mohammed Al-Saadi, Eleni Michalopoulou, Ranieri Verin, Martina Dettwiler, Heli Nordgren, Koen Chiers, Ernst Groβmann, Kernt Köhler and 3 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Molecular detection and evaluation of bovine gammaherpesvirus 6 (BoGHV6) in semen and genital tract of bulls from Mato Grosso State, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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  9. Quantification of ovine gammaherpesvirus 2 in clinical cases of cattle with sheep-associated malignant catarrhal fever.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  10. Malignant catarrhal fever in a goat: manifestation of virus-induced erythema multiforme.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Giuliana RosatoVetsuisse Faculty, Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 268, 8057 Zurich, Switzerland.
Andres Ruiz SubiraVetsuisse Faculty, Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 268, 8057 Zurich, Switzerland.
Mohammed Al-SaadiDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK.
Eleni MichalopoulouDepartment of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston CH64 7TE, UK.ORCID 0000-0003-2564-3267
Ranieri VerinDepartment of Veterinary Pathology and Public Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston CH64 7TE, UK.ORCID 0000-0001-9366-5682
Martina DettwilerDepartment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland.ORCID 0000-0001-9404-7122
Heli NordgrenDepartment of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Agnes Sjöbergin katu 2, 00014 Helsinki, Finland.
Koen ChiersDepartment of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Ernst GroβmannAulendorf State Veterinary Diagnostic Centre, Löwenbreitestrasse 18/20, 88326 Aulendorf, Germany.
Kernt KöhlerFaculty of Veterinary Medicine, Institute of Veterinary Pathology, Justus-Liebig-University Giessen, Frankfurter Strasse 96, 35390 Giessen, Germany.
Michael SuntzState Institute for Chemical and Veterinary Analysis Freiburg, Bissierstrasse 5, 79114 Freiburg im Breisgau, Germany.
James P StewartDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK.ORCID 0000-0002-8928-2037
Anja KiparVetsuisse Faculty, Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 268, 8057 Zurich, Switzerland.ORCID 0000-0001-7289-3459
University of Liverpool · GBUniversity of Helsinki · FIUniversity of Zurich · CHGhent University · BEJustus-Liebig-Universität Gießen · DEUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genus Macavirus, subfamily Gammaherpesvirinae, comprises ungulate viruses that infect domestic and wild ruminants and swine. They cause asymptomatic latent infections in reservoir hosts and malignant catarrhal fever in susceptible species. Lung, spleen, bronchial lymph node, and tongue were collected from 448 cattle (348 necropsied, 100 slaughtered) in Switzerland, United Kingdom, Finland, Belgium, and Germany to determine their infection with bovine herpesvirus-6 (BoHV-6) and gammaherpesviruses of other ruminants, i.e., ovine herpesvirus-1 and -2, caprine herpesvirus-2, and bison lymphotropic herpesvirus, using quantitative PCR. Only BoHV-6 was detected, with an overall frequency of 32%, ranging between 22% and 42% in the different countries. Infection was detected across all ages, from one day after birth, and was positively correlated with age. There was no evidence of an association with specific disease processes. In positive animals, BoHV-6 was detected in all organs with high frequency, consistently in the lungs or spleen. Viral loads varied substantially. In BoHV-6-positive gravid cows, organs of fetuses tested negative for infection, indicating that the virus is not vertically transmitted. Our results confirm previous data indicating that BoHV-6 is a commensal of domestic cattle not associated with disease processes and confirm that infections with other macaviruses are rare and sporadic.

Indexed as

Herpesviridae InfectionsAnimalsCattleCattle DiseasesEuropeHerpesviridaeBoHV-6commensalEuropean cattlegammaherpesvirusqPCR

Identifiers

PMID34960607
PMCPMC8709109
OpenAlexW3215201436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.