Evidence map›Paper›PMID 34960604›Full record

ArticleViruses2021

Eurasian Avian-like M1 Plays More Important Role than M2 in Pathogenicity of 2009 Pandemic H1N1 Influenza Virus in Mice.

Lixiang Xie, Guanlong Xu, Lingxiang Xin, Zhaofei Wang, Rujuan Wu, Mingqing Wu, Yuqiang Cheng, Hengan Wang, Yaxian Yan, Jingjiao Ma and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lixiang XieSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Guanlong XuChina Institute of Veterinary Drug Control, Beijing 100081, China.
Lingxiang XinChina Institute of Veterinary Drug Control, Beijing 100081, China.
Zhaofei WangSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Rujuan WuSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Mingqing WuSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Yuqiang ChengSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Hengan WangSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Yaxian YanSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Jingjiao MaSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-1187-7249
Jianhe SunSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Shanghai Jiao Tong University · CNChina Institute of Veterinary Drug Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reassortant variant viruses generated between 2009 H1N1 pandemic influenza virus [A(H1N1)pdm09] and endemic swine influenza viruses posed a potential risk to humans. Surprisingly, genetic analysis showed that almost all of these variant viruses contained the M segment from A(H1N1)pdm09, which originated from Eurasian avian-like swine influenza viruses. Studies have shown that the A(H1N1)pdm09 M gene is critical for the transmissibility and pathogenicity of the variant viruses. However, the M gene encodes two proteins, M1 and M2, and which of those plays a more important role in virus pathogenicity remains unknown. In this study, the M1 and M2 genes of A(H1N1)pdm09 were replaced with those of endemic H3N2 swine influenza virus, respectively. The chimeric viruses were rescued and evaluated

Indexed as

AnimalsDogsFemaleHEK293 CellsHumansInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMadin Darby Canine Kidney CellsMiceMice, Inbred BALB COrthomyxoviridae InfectionsSwineSwine DiseasesViral Matrix ProteinsViroporin ProteinsM1 protein, Influenza A virusM2 protein, Influenza A virusViral Matrix ProteinsViroporin Proteins2009 H1N1 pandemicEurasian avian-likeinfluenzaM1M2pathogenicity

Identifiers

PMID34960604
PMCPMC8707482
OpenAlexW3215776359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.