Evidence map›Paper›PMID 34960595›Full record

ArticleSensors (Basel, Switzerland)2021

Predictive Machine Learning Models and Survival Analysis for COVID-19 Prognosis Based on Hematochemical Parameters.

Nicola Altini, Antonio Brunetti, Stefano Mazzoleni, Fabrizio Moncelli, Ilenia Zagaria, Berardino Prencipe, Erika Lorusso, Enrico Buonamico, Giovanna Elisiana Carpagnano, Davide Fiore Bavaro and 8 more

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nicola AltiniDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0001-7353-4968
Antonio BrunettiDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0002-1934-0983
Stefano MazzoleniDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0002-9528-3239
Fabrizio MoncelliDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0001-7521-3148
Ilenia ZagariaDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.
Berardino PrencipeDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0002-1985-1142
Erika LorussoDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.
Enrico BuonamicoInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0001-6348-1356
Giovanna Elisiana CarpagnanoInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0001-7931-4704
Davide Fiore BavaroClinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-4833-7118
Mariacristina PolisenoClinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-9896-489X
Annalisa SaracinoClinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0001-9558-208X
Annalisa SchirinziClinic Pathology Unit, University Hospital of Bari, 70124 Bari, Italy.ORCID 0000-0001-9826-7907
Riccardo LaterzaClinic Pathology Unit, University Hospital of Bari, 70124 Bari, Italy.ORCID 0000-0001-5503-1478
Francesca Di SerioClinic Pathology Unit, University Hospital of Bari, 70124 Bari, Italy.
Alessia D'IntronoInternal Medicine Unit, Ostuni Hospital, 72017 Ostuni, Italy.ORCID 0000-0002-3595-7094
Francesco PesceNephrology Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-2882-4226
Vitoantonio BevilacquaDepartment of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0002-3088-0788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of millions of individuals and caused millions of deaths worldwide. Predicting the clinical course of the disease is of pivotal importance to manage patients. Several studies have found hematochemical alterations in COVID-19 patients, such as inflammatory markers. We retrospectively analyzed the anamnestic data and laboratory parameters of 303 patients diagnosed with COVID-19 who were admitted to the Polyclinic Hospital of Bari during the first phase of the COVID-19 global pandemic. After the pre-processing phase, we performed a survival analysis with Kaplan-Meier curves and Cox Regression, with the aim to discover the most unfavorable predictors. The target outcomes were mortality or admission to the intensive care unit (ICU). Different machine learning models were also compared to realize a robust classifier relying on a low number of strongly significant factors to estimate the risk of death or admission to ICU. From the survival analysis, it emerged that the most significant laboratory parameters for both outcomes was

Indexed as

COVID-19Hospital MortalityHumansMachine LearningPrognosisRetrospective StudiesSARS-CoV-2Survival AnalysisCOVID-19Cox regressionhematochemical parametersKaplan–Meiermachine learningprognostic markers

Identifiers

PMID34960595
PMCPMC8705488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.