Evidence map›Paper›PMID 34960199›Full record

ArticleVaccines2021

Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against

Cansu Karyal, Panayiota Palazi, Jaime Hughes, Rhys C Griffiths, Ruby R Persaud, Patrick J Tighe, Nicholas J Mitchell, Ruth Griffin

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. In Vivo Evaluation of PamJournal of peptide science : an official publication of the European Peptide Society · 2025
    Article
  3. Article
  4. Immunization Strategies Against Clostridioides difficile.Advances in experimental medicine and biology · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cansu KaryalSynthetic Biology Research Centre, School of Life Sciences, The University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.
Panayiota PalaziSchool of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.
Jaime HughesSynthetic Biology Research Centre, School of Life Sciences, The University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.
Rhys C GriffithsSchool of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.
Ruby R PersaudInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, The University of Birmingham, Birmingham B15 2TT, UK.
Patrick J TigheSchool of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0001-8326-093X
Nicholas J MitchellSchool of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-9041-1852
Ruth GriffinSynthetic Biology Research Centre, School of Life Sciences, The University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.ORCID 0000-0002-0269-059X
University of Nottingham · GBNottingham University Hospitals NHS Trust · GBUniversity of Birmingham · GB

Funding

Medical Research Council MC_PC_17173
6 · The paper itself

Abstract

Mucosal vaccination aims to prevent infection mainly by inducing secretory IgA (sIgA) antibody, which neutralises pathogens and enterotoxins by blocking their attachment to epithelial cells. We previously demonstrated that encapsulated protein antigen CD0873 given orally to hamsters induces neutralising antibodies locally as well as systemically, affording partial protection against

Indexed as

Clostridioides difficileIgGlipidationliposomesoral vaccinerecombinant proteinsIgA

Identifiers

PMID34960199
PMCPMC8708880
OpenAlexW4200252754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.