Evidence map›Paper›PMID 34960126›Full record

ArticleVaccines2021

PICK-ing Malaysia's Epidemic Apart: Effectiveness of a Diverse COVID-19 Vaccine Portfolio.

Jing Lian Suah, Peter Seah Keng Tok, Su Miin Ong, Masliyana Husin, Boon Hwa Tng, Sheamini Sivasampu, Thevesh Thevananthan, Maheshwara Rao Appannan, Faizah Muhamad Zin, Shahanizan Mohd Zin and 6 more

Abstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  14. Characteristics and factors associated with severity of COVID-19 infections in primary care.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jing Lian SuahCOVID-19 Immunisation Task Force, Government of Malaysia, Putrajaya 62000, Malaysia.ORCID 0000-0003-0908-3597
Peter Seah Keng TokInstitute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia.
Su Miin OngInstitute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia.
Masliyana HusinInstitute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia.
Boon Hwa TngCOVID-19 Immunisation Task Force, Government of Malaysia, Putrajaya 62000, Malaysia.
Sheamini SivasampuInstitute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia.ORCID 0000-0003-2314-6048
Thevesh ThevananthanCOVID-19 Immunisation Task Force, Government of Malaysia, Putrajaya 62000, Malaysia.
Maheshwara Rao AppannanDisease Control Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Faizah Muhamad ZinMedical Development Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Shahanizan Mohd ZinMedical Development Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Hazlina YahayaDisease Control Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Norhayati RusliDisease Control Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Mohd Fikri UjangMedical Development Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Hishamshah Mohd IbrahimOffice of Director-General, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Noor Hisham AbdullahOffice of Director-General, Ministry of Health Malaysia, Putrajaya 62590, Malaysia.
Kalaiarasu M PeariasamyInstitute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia.ORCID 0000-0001-9279-3498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaysia rolled out a diverse portfolio of predominantly three COVID-19 vaccines (AZD1222, BNT162b2, and CoronaVac) beginning 24 February 2021. We evaluated vaccine effectiveness with two methods, covering 1 April to 15 September 2021: (1) the screening method for COVID-19 (SARS-CoV-2) infection and symptomatic COVID-19; and (2) a retrospective cohort of confirmed COVID-19 cases for COVID-19 related ICU admission and death using logistic regression. The screening method estimated partial vaccination to be 48.8% effective (95% CI: 46.8, 50.7) against COVID-19 infection and 33.5% effective (95% CI: 31.6, 35.5) against symptomatic COVID-19. Full vaccination is estimated at 87.8% effective (95% CI: 85.8, 89.7) against COVID-19 infection and 85.4% effective (95% CI: 83.4, 87.3) against symptomatic COVID-19. Among the cohort of confirmed COVID-19 cases, partial vaccination with any of the three vaccines is estimated at 31.3% effective (95% CI: 28.5, 34.1) in preventing ICU admission, and 45.1% effective (95% CI: 42.6, 47.5) in preventing death. Full vaccination with any of the three vaccines is estimated at 79.1% effective (95% CI: 77.7, 80.4) in preventing ICU admission and 86.7% effective (95% CI: 85.7, 87.6) in preventing deaths. Our findings suggest that full vaccination with any of the three predominant vaccines (AZD1222, BNT162b2, and CoronaVac) in Malaysia has been highly effective in preventing COVID-19 infection, symptomatic COVID-19, COVID-19-related ICU admission, and death.

Indexed as

cohort studyCOVID-19COVID-19 vaccinesMalaysiaSARS-CoV-2vaccine effectiveness

Identifiers

PMID34960126
PMCPMC8706086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.