Evidence map›Paper›PMID 34960078›Full record

ArticleNutrients2021

Corticosterone and Glucocorticoid Receptor in the Cortex of Rats during Aging-The Effects of Long-Term Food Restriction.

Vesna Tesic, Jelena Ciric, Irena Jovanovic Macura, Nevena Zogovic, Desanka Milanovic, Selma Kanazir, Milka Perovic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. The Lemon Flavonoid EriominInternational journal of molecular sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vesna TesicDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11060 Belgrade, Serbia.
Jelena CiricDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11060 Belgrade, Serbia.
Irena Jovanovic MacuraDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11060 Belgrade, Serbia.
Nevena ZogovicDepartment of Neurophysiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0003-4240-3193
Desanka MilanovicDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11060 Belgrade, Serbia.
Selma KanazirDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0002-7229-5296
Milka PerovicDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Bul. despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0003-0941-6988
University of Belgrade · RS

Funding

Ministry of Education, Science and Technological Development of the Republic of Serbia 451-03-9/2021-14/200007
6 · The paper itself

Abstract

Numerous beneficial effects of food restriction on aging and age-related pathologies are well documented. It is also well-established that both short- and long-term food restriction regimens induce elevated circulating levels of glucocorticoids, stress-induced hormones produced by adrenal glands that can also exert deleterious effects on the brain. In the present study, we examined the effect of long-term food restriction on the glucocorticoid hormone/glucocorticoid receptor (GR) system in the cortex during aging, in 18- and 24-month-old rats. Corticosterone level was increased in the cortex of aged ad libitum-fed rats. Food restriction induced its further increase, accompanied with an increase in the level of 11β-hydroxysteroid dehydrogenase type 1. However, alterations in the level of GR phosphorylated at Ser

Indexed as

Food Deprivation11-beta-Hydroxysteroid Dehydrogenase Type 1AgingAnimalsbcl-2-Associated X ProteinCerebral CortexCorticosteroneCyclin-Dependent Kinase 5Gene Expression RegulationGlial Fibrillary Acidic ProteinHSP90 Heat-Shock ProteinsMaleNeuroprotectionNF-kappa BProto-Oncogene Proteins c-fosRandom Allocation11-beta-Hydroxysteroid Dehydrogenase Type 1bcl-2-Associated X ProteinCdk5 protein, ratCorticosteroneCyclin-Dependent Kinase 5Gfap protein, ratGlial Fibrillary Acidic ProteinHSP90 Heat-Shock ProteinsNF-kappa BProto-Oncogene Proteins c-fosReceptors, GlucocorticoidRNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding Proteins11β-HSD1c-fosfood restrictionglucocorticoidsGRα isoformsintermittent fasting

Identifiers

PMID34960078
PMCPMC8703853
OpenAlexW4200228791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.