ArticleNutrients2021
Excess Vitamins or Imbalance of Folic Acid and Choline in the Gestational Diet Alter the Gut Microbiota and Obesogenic Effects in Wistar Rat Offspring.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Gut microbiota bridges dietary nutrients and host immunity.Science China. Life sciences · 2023Pooled it
- Eyes on Development: Exploring the Impact of Early Life Nutrition Exposures on Child Cognition Through Eye-Tracking Assessment.Nutrition reviews · 2026Article
- Prenatal Choline and Betaine Differentially Program Adult Hepatic One-Carbon Metabolism in Wistar Rats.Journal of agricultural and food chemistry · 2026Article
- Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights.Current nutrition reports · 2026Review
- Prenatal Methyl Nutrient Availability Shapes Mesolimbic Dopaminergic Circuitry and Systemic Inflammation in Wistar Rat Offspring of Both Sexes.Journal of neurochemistry · 2026Article
- Distinct Gut Microbiota Signatures Characterize Glucoregulatory Effects of Prenatal Choline and Betaine in Wistar Rat Offspring.The Journal of nutrition · 2026Article
- Prenatal Intake of High Multivitamins or Folic Acid With or Without Choline Contributes to Gut Microbiota-Associated Dysregulation of Serotonin in Offspring.Molecular nutrition & food research · 2025Article
- Folic acid alleviates the negative effects of dexamethasone induced stress on production performance in Hyline Brown laying hens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Combined effects of maternal supplementation of iron, calcium, folic acid, and multivitamin during pregnancy on obesity in Chinese preschoolers born macrosomia.Frontiers in pediatrics · 2025Article
- Role of folic acid in regulating gut microbiota and short-chain fatty acids based on an in vitro fermentation model.Applied microbiology and biotechnology · 2024Article
- Choline-An Underappreciated Component of a Mother-to-Be's Diet.Nutrients · 2024Review
- Review
- Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Article
- Review
- Modification of the serotonergic systems and phenotypes by gestational micronutrients.The Journal of endocrinology · 2023Article
- Dietary folic acid addition reduces abdominal fat deposition mediated by alterations in gut microbiota and SCFA production in broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Factors Affecting Gut Microbiota of Puppies from Birth to Weaning.Animals : an open access journal from MDPI · 2023Review
- In utero choline exposure alters growth, metabolism, feed efficiency, and carcass characteristics of Holstein × Angus cattle from weaning to slaughter.Journal of animal science · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Excess vitamin intake during pregnancy leads to obesogenic phenotypes, and folic acid accounts for many of these effects in male, but not in female, offspring. These outcomes may be modulated by another methyl nutrient choline and attributed to the gut microbiota. Pregnant Wistar rats were fed an AIN-93G diet with recommended vitamin (RV), high 10-fold multivitamin (HV), high 10-fold folic acid with recommended choline (HFol) or high 10-fold folic acid without choline (HFol-C) content. Male and female offspring were weaned to a high-fat RV diet for 12 weeks post-weaning. Removing choline from the HFol gestational diet resulted in obesogenic phenotypes that resembled more closely to HV in male and female offspring with higher body weight, food intake, glucose response to a glucose load and body fat percentage with altered activity, concentrations of short-chain fatty acids and gut microbiota composition. Gestational diet and sex of the offspring predicted the gut microbiota differences. Differentially abundant microbes may be important contributors to obesogenic outcomes across diet and sex. In conclusion, a gestational diet high in vitamins or imbalanced folic acid and choline content contributes to the gut microbiota alterations consistent with the obesogenic phenotypes of in male and female offspring.
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Registered trials
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