Evidence map›Paper›PMID 34960061›Full record

Trial reportNutrients2021

Chee-Sieng Khor, Ryohei Tsuji, Hai-Yen Lee, Siti-Sarah Nor'e, Norhidayu Sahimin, Adzzie-Shazleen Azman, Vunjia Tiong, Pouya Hasandarvish, Boon-Teong Teoh, Yih-Harng Soh and 5 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Frontiers in immunology · 2025
    Pooled it
  2. Review
  3. Effects ofTropical medicine and infectious disease · 2026
    Article
  4. Article
  5. Potential of Synbiotics and Probiotics as Chemopreventive Agent.Probiotics and antimicrobial proteins · 2024
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Chee-Sieng KhorTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0003-2883-3031
Ryohei TsujiKirin Central Research Institute, Kirin Holdings Co., Ltd., Yokohama 236-0004, Japan.ORCID 0000-0002-8547-6846
Hai-Yen LeeTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0001-6322-6718
Siti-Sarah Nor'eTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Norhidayu SahiminTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0003-1457-2758
Adzzie-Shazleen AzmanTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Vunjia TiongTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Pouya HasandarvishTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Boon-Teong TeohTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Yih-Harng SohTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0003-1239-5903
Jian-Hai ChaiTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Takeshi KokuboKirin Central Research Institute, Kirin Holdings Co., Ltd., Yokohama 236-0004, Japan.
Osamu KanauchiResearch and Development Strategy Department, Kirin Holdings Co., Ltd., Tokyo 164-0001, Japan.
Naoki YamamotoGenome Medical Sciences Project, National Center for Global Health and Medicine, Chiba 272-8516, Japan.
Sazaly AbuBakarTropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-9267-1420
University of Malaya · MYKirin (Japan) · JPTokyo Medical and Dental University · JP

Funding

Kirin (Japan) KRN19001447Ministry of Education Malaysia MO002-2019
6 · The paper itself

Abstract

Dengue fever (DF) is a mosquito-borne disease still with no effective treatment or vaccine available. A randomized, placebo-controlled, double-blinded, parallel-group trial was undertaken to evaluate the efficacy of oral intake of

Indexed as

Administration, OralAdultDengueDengue VirusDouble-Blind MethodFemaleHumansLactococcus lactisMalaysiaMaleProbioticsTreatment Outcomedengue feverdengue viruslactic acid bacteriaLactococcus lactisLC-Plasma

Identifiers

PMID34960061
PMCPMC8707015
OpenAlexW4200206863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.