Evidence map›Paper›PMID 34960054›Full record

ArticleNutrients2021

Kyeong-Min Kim, So-Yeon Kim, Tamanna Jahan Mony, Ho Jung Bae, Sang-Deok Han, Eun-Seok Lee, Seung-Hyuk Choi, Sun Hee Hong, Sang-Deok Lee, Se Jin Park

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Phytochemical Diversity and Antioxidant Potential ofAntioxidants (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
  4. A Comprehensive Review of the Phenolic Compounds inMolecules (Basel, Switzerland) · 2025
    Review
  5. Total flavonoids ofFrontiers in pharmacology · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Frontiers in nutrition · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kyeong-Min KimDepartment of Food Biotechnology and Environmental Science, School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea.
So-Yeon KimDepartment of Food Biotechnology and Environmental Science, School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea.ORCID 0000-0003-1885-0540
Tamanna Jahan MonyAgriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Korea.
Ho Jung BaeAgriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Korea.
Sang-Deok HanDepartment of Food Biotechnology and Environmental Science, School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea.
Eun-Seok LeeDepartment of Food Biotechnology and Environmental Science, School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea.
Seung-Hyuk ChoiDepartment of Food Biotechnology and Environmental Science, School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea.
Sun Hee HongSchool of Applied Science in Natural Resources & Environment, Hankyong National University, Anseong 17579, Korea.ORCID 0000-0001-7581-0604
Sang-Deok LeeDivision of Forest Science, Kangwon National University, Chuncheon 24341, Korea.
Se Jin ParkDepartment of Food Biotechnology and Environmental Science, School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea.
Kangwon National University · KRHankyong National University · KR

Funding

the Basic Science Research Program through the National Research Foundation of Korea (NRF) founded by the Ministry of Education NRF-2021R1A6A1A03044242the Korean Ministry of Environment 2018002270002the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT & Future Planning NRF-2020R1C1C1004911
6 · The paper itself

Abstract

The excessive synthesis of interleukin-6 (IL-6) is related to cytokine storm in COVID-19 patients. Moreover, blocking IL-6 has been suggested as a treatment strategy for inflammatory diseases such as sepsis. Sepsis is a severe systemic inflammatory response syndrome with high mortality. In the present study, we investigated the anti-inflammatory and anti-septic effects and the underlying mechanisms of

Indexed as

AnimalsEthanolExtracellular Signal-Regulated MAP KinasesInflammationInterleukin-6LamiaceaeLipopolysaccharidesMaleMAP Kinase Kinase 4MAP Kinase Signaling SystemMicePlant ExtractsRAW 264.7 CellsTranscription Factor RelAEthanolExtracellular Signal-Regulated MAP KinasesInterleukin-6interleukin-6, mouseLipopolysaccharidesMAP Kinase Kinase 4Plant ExtractsRela protein, mouseTranscription Factor RelADracocephalum moldavicainflammationinterleukin-6lipopolysaccharidesepsis

Identifiers

PMID34960054
PMCPMC8706341
OpenAlexW4200224407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.