Evidence map›Paper›PMID 34960037›Full record

Trial reportNutrients2021

Synbiotics Easing Renal Failure by Improving Gut Microbiology II (SYNERGY II): A Feasibility Randomized Controlled Trial.

Catherine McFarlane, Rathika Krishnasamy, Tony Stanton, Emma Savill, Matthew Snelson, Gabor Mihala, Jaimon T Kelly, Mark Morrison, David W Johnson, Katrina L Campbell

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Review
  11. Review
  12. Gut-kidney axis: Dysbiosis and renal disease.World journal of nephrology · 2026
    Review
  13. Review
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  15. Article
  16. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Catherine McFarlaneSchool of Medicine, University of Queensland, Brisbane, QLD 4006, Australia.ORCID 0000-0002-9546-0346
Rathika KrishnasamySunshine Coast University Hospital, Birtinya, QLD 4575, Australia.
Tony StantonSunshine Coast University Hospital, Birtinya, QLD 4575, Australia.
Emma SavillSunshine Coast University Hospital, Birtinya, QLD 4575, Australia.
Matthew SnelsonDepartment of Diabetes, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0003-4829-9550
Gabor MihalaSchool of Medicine and Dentistry, Griffith University, Brisbane, QLD 4111, Australia.
Jaimon T KellyMenzies Health Institute Queensland, Griffith University, Brisbane, QLD 4111, Australia.ORCID 0000-0003-0232-5848
Mark MorrisonDiamantina Institute, Faculty of Medicine, University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0001-9257-9133
David W JohnsonAustralasian Kidney Trials Network, University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0001-5491-3460
Katrina L CampbellMenzies Health Institute Queensland, Griffith University, Brisbane, QLD 4111, Australia.
Griffith University · AUThe University of Queensland · AUMonash University · AUSunshine Coast University Hospital · AU

Funding

BEAT-CKD via Australasian Kidney Trial Network NAPA Research Foundation NAStudy Education and Research Trust Fund, Sunshine Coast NAWishlist NA
6 · The paper itself

Abstract

Synbiotics have emerged as a therapeutic strategy for modulating the gut microbiome and targeting novel cardiovascular risk factors, including uremic toxins indoxyl sulfate (IS) and

Indexed as

SynbioticsAgedDouble-Blind MethodFeasibility StudiesFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedRenal Insufficiencygastrointestinal microbiomeindoxyl sulfatekidney diseasep-cresyl sulphaterandomized controlled trialsynbiotic

Identifiers

PMID34960037
PMCPMC8708915
OpenAlexW4200449952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.