Evidence map›Paper›PMID 34960021›Full record

Trial reportNutrients2021

Effects of Malted Rice Amazake on Constipation Symptoms and Gut Microbiota in Children and Adults with Severe Motor and Intellectual Disabilities: A Pilot Study.

Suzumi Kageyama, Rikako Inoue, Koji Hosomi, Jonguk Park, Hitomi Yumioka, Tomo Suka, Yoshihiro Kurohashi, Kazuaki Teramoto, A Yasmin Syauki, Miki Doi and 4 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. International journal of molecular sciences · 2025
    Article
  2. Article
  3. HarnessingFoods (Basel, Switzerland) · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Suzumi KageyamaGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Rikako InoueDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.ORCID 0000-0002-1723-2444
Koji HosomiLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.
Jonguk ParkArtificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.ORCID 0000-0003-4872-385X
Hitomi YumiokaLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.
Tomo SukaDepartment of Rehabilitation, Kishu Rehabilitation Visiting Care Station, Wakayama 640-0332, Japan.
Yoshihiro KurohashiDepartment of Rehabilitation, Kishu Rehabilitation Visiting Care Station, Wakayama 640-0332, Japan.
Kazuaki TeramotoDepartment of Rehabilitation, Kishu Rehabilitation Visiting Care Station, Wakayama 640-0332, Japan.
A Yasmin SyaukiGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Miki DoiGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Haruka SakaueGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Kenji MizuguchiArtificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.ORCID 0000-0003-3021-7078
Jun KunisawaLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.
Yasuyuki IrieDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.

Funding

Japan Agency for Medical Research and Development (AMED) JP20gm1010006h004Ministry of Health and Welfare of Japan and Public /Private R&D Investment Strategic Expansion PrograM: PRISM 20AC5004Okayama Prefectural University Creative Research Grant 2019C08
6 · The paper itself

Abstract

Constipation is a frequent complication in patients with severe motor and intellectual disabilities (SMID). The aim of this study was to investigate changes in constipation symptoms and gut microbiota associated with the intake of malted rice amazake, a fermented food in Japan, in patients with SMID. Ten patients consumed the test food for six weeks, and their physical condition, dietary and medication status, and constipation assessment scale (CAS) were investigated. Comprehensive fecal microbiome analysis using the 16S rRNA sequence method was performed. The results showed a significant decrease in CAS, and a significant increase in Lactobacillales and decrease in

Indexed as

Intellectual DisabilityOryzaPersons with DisabilitiesSeedlingsAdultBacteriaChildConstipationFecesFemaleGastrointestinal MicrobiomeHumansMalePilot ProjectsRNA, BacterialRNA, Ribosomal, 16SRNA, BacterialRNA, Ribosomal, 16S16S rRNAconstipationconstipation assessment scale (CAS)gut microbiotamalted rice amazakesevere motor and intellectual disabilities

Identifiers

PMID34960021
PMCPMC8705246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.