Evidence map›Paper›PMID 34959977›Full record

ReviewNutrients2021

Pancreatic Cancer and Gut Microbiome-Related Aspects: A Comprehensive Review and Dietary Recommendations.

Bartosz Kamil Sobocki, Karolina Kaźmierczak-Siedlecka, Marcin Folwarski, Viktoria Hawryłkowicz, Wojciech Makarewicz, Ewa Stachowska

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06199752 (Synergistic Immunomodulatory Effect of Synbiotics Pre and Postoperative Resection of Pancreatic Ductal Adenocarcinoma), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06199752 phase4completednot on this map

Synergistic Immunomodulatory Effect of Synbiotics Pre and Postoperative Resection of Pancreatic Ductal Adenocarcinoma

TypeinterventionalSponsorTheodor Bilharz Research InstituteRan2021 to 2023Enrolled90ConditionsPancreatic Ductal AdenocarcinomaArmsprobiotic agent 25 Billion CFU (Nowfoods, USA) , ). Inulin capsules 1000mg Herbamama USA
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Dysbiosis and extraintestinal cancers.Journal of experimental & clinical cancer research : CR · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bartosz Kamil SobockiScientific Circle of Oncology and Radiotherapy, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-5074-9701
Karolina Kaźmierczak-SiedleckaDepartment of Surgical Oncology, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-0283-1436
Marcin FolwarskiDepartment of Clinical Nutrition and Dietetics, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-7301-1689
Viktoria HawryłkowiczDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Wojciech MakarewiczDepartment of Surgical Oncology, Medical University of Gdansk, 80-210 Gdańsk, Poland.
Ewa StachowskaDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Gdańsk Medical University · PLPomeranian Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota plays a significant role in the human body providing many beneficial effects on the host. However, its dysbiotic alterations may affect the tumorigenic pathway and then trigger the development of pancreatic cancer. This dysbiosis can also modulate the aggressiveness of the tumor, influencing the microenvironment. Because pancreatic cancer is still one of the most lethal cancers worldwide with surgery as the only method that influences prognosis and has curative potential, there is a need to search for other strategies which will enhance the efficiency of standard therapy and improve patients' quality of life. The administration of prebiotics, probiotics, next-generation probiotics (

Indexed as

Gastrointestinal MicrobiomeDysbiosisFecal Microbiota TransplantationHumansPancreatic NeoplasmsPrebioticsProbioticsSynbioticsTumor MicroenvironmentPrebioticsfecal microbiota transplantationgut microbiotanext-generation probioticspancreatic cancerpostbioticsprebioticsprobioticssynbiotics

Identifiers

PMID34959977
PMCPMC8709322
OpenAlexW4200382551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.