Trial reportNutrients2021
Goji Berry Intake Increases Macular Pigment Optical Density in Healthy Adults: A Randomized Pilot Trial.
Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of Long-Term Supplementation withNutrients · 2026Trial
- Pistachio Consumption Increases Macular Pigment Optical Density in Healthy Adults: A Randomized Controlled Trial.The Journal of nutrition · 2025Trial
- Bioactive spectrum of goji berries (Food chemistry: X · 2026Review
- Review
- Edible Berries-An Update on Nutritional Composition and Health Benefits-Part II.Current nutrition reports · 2025Review
- Superfoods in Drug Discovery: Nutrient Profiles and their Emerging Health Benefits.Current drug discovery technologies · 2025Review
- Review
- Berries and Their Active Compounds in Prevention of Age-Related Macular Degeneration.Antioxidants (Basel, Switzerland) · 2024Review
- Young Goji Fruit Volatiles Regulate the Oviposition Behavior and Chemosensory Gene Expression of Gravid FemaleInternational journal of molecular sciences · 2024Article
- The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways.Plants (Basel, Switzerland) · 2024Review
- Selection and Validation of Reference Genes for Gene Expression inInternational journal of molecular sciences · 2024Article
- Perspective: Challenges and Future Directions in Clinical Research with Nuts and Berries.Advances in nutrition (Bethesda, Md.) · 2023Article
- A Low-Cost Fertilizer Medium Supplemented with Urea for the Lutein Production ofBioengineering (Basel, Switzerland) · 2023Article
- Potential roles of dietary zeaxanthin and lutein in macular health and function.Nutrition reviews · 2023Review
- Blue Light-Ocular and Systemic Damaging Effects: A Narrative Review.International journal of molecular sciences · 2023Review
- Distinct Role ofPharmaceuticals (Basel, Switzerland) · 2023Review
- Transcriptome-Based Selection and Validation of Reference Genes for Gene Expression in Goji Fruit Fly (International journal of molecular sciences · 2022Article
- Assessment of the Bioaccessibility of Carotenoids in Goji Berry (Foods (Basel, Switzerland) · 2022Article
- Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2022Review
- Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related macular degeneration (AMD) is the third leading cause of blindness worldwide. Macular pigment optical density (MPOD), a biomarker for AMD, is a non-invasive measure to assess risk. The macula xanthophyll pigments lutein (L) and zeaxanthin (Z) protect against blue light and provide oxidant defense, which can be indexed by MPOD. This study examined the effects of Z-rich goji berry intake on MPOD and skin carotenoids in healthy individuals. A randomized, unmasked, parallel-arm study was conducted with 27 participants, aged 45-65, who consumed either 28 g of goji berries or a supplement containing 6 mg L and 4 mg Z (LZ), five times weekly for 90 days. After 90 days, MPOD was significantly increased in the goji berry group at 0.25 and 1.75 retinal eccentricities (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.