Evidence map›Paper›PMID 34959959›Full record

ArticleNutrients2021

Preferential Metabolic Improvement by Intermittent Fasting in People with Elevated Baseline Red Cell Distribution Width: A Secondary Analysis of the WONDERFUL Randomized Controlled Trial.

Benjamin D Horne, Joseph B Muhlestein, Heidi T May, Viet T Le, Tami L Bair, Sterling T Bennett, Kirk U Knowlton, Jeffrey L Anderson

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Intermittent fasting and changes in clinical risk scores: Secondary analysis of a randomized controlled trial.International journal of cardiology. Cardiovascular risk and prevention · 2023
    Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Benjamin D HorneIntermountain Medical Center Heart Institute, Salt Lake City, UT 84107, USA.ORCID 0000-0002-2656-0263
Joseph B MuhlesteinIntermountain Medical Center Heart Institute, Salt Lake City, UT 84107, USA.
Heidi T MayIntermountain Medical Center Heart Institute, Salt Lake City, UT 84107, USA.
Viet T LeIntermountain Medical Center Heart Institute, Salt Lake City, UT 84107, USA.ORCID 0000-0001-6659-5332
Tami L BairIntermountain Medical Center Heart Institute, Salt Lake City, UT 84107, USA.
Sterling T BennettIntermountain Central Laboratory, Intermountain Medical Center, Salt Lake City, UT 84107, USA.
Kirk U KnowltonIntermountain Medical Center Heart Institute, Salt Lake City, UT 84107, USA.
Jeffrey L AndersonIntermountain Medical Center Heart Institute, Salt Lake City, UT 84107, USA.
Intermountain Medical Center · USUniversity of Utah · US

Funding

Intermountain Research and Medical Foundation 759Intermountain Research and Medical Foundation Dell Loy Hansen Heart Foundation
6 · The paper itself

Abstract

Red cell distribution width (RDW) predicts cardiovascular outcomes, but it is unstudied with regard to intermittent fasting. In WONDERFUL trial subjects, the effect of the interaction between baseline RDW and intermittent fasting on changes in insulin and other cardiometabolic endpoints and the effect of fasting on changes in RDW were evaluated. The subjects enrolled were aged 21-70 years and were free of statins, anti-diabetes medications, and chronic diseases, and had ≥1 metabolic syndrome feature, as well as elevated low-density lipoprotein cholesterol. Subjects were randomized to 24-h, water-only fasting (twice per week for 4 weeks, once per week for 22 weeks) or 26 weeks of ad libitum eating. Subjects (N = 71;

Indexed as

Erythrocyte IndicesRandomized Controlled Trials as TopicAdultAgedBiomarkersCardiovascular DiseasesCholesterol, LDLFastingFemaleHeart Disease Risk FactorsHumansInsulinMaleMiddle AgedYoung AdultBiomarkersCholesterol, LDLInsulinintermittent fastingRDWRDW-CVRDW-SDtherapeutic fasting

Identifiers

PMID34959959
PMCPMC8703681
OpenAlexW4200233987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.