Evidence map›Paper›PMID 34959947›Full record

ArticleNutrients2021

Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake.

Nora Eszlari, Bence Bruncsics, Andras Millinghoffer, Gabor Hullam, Peter Petschner, Xenia Gonda, Gerome Breen, Peter Antal, Gyorgy Bagdy, John Francis William Deakin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Nora EszlariDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.ORCID 0000-0003-4913-028X
Bence BruncsicsDepartment of Measurement and Information Systems, Budapest University of Technology and Economics, Magyar Tudósok krt. 2, H-1521 Budapest, Hungary.
Andras MillinghofferNAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.
Gabor HullamDepartment of Measurement and Information Systems, Budapest University of Technology and Economics, Magyar Tudósok krt. 2, H-1521 Budapest, Hungary.
Peter PetschnerDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.
Xenia GondaNAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.ORCID 0000-0001-9015-4203
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Memory Lane, London SE5 8AF, UK.
Peter AntalDepartment of Measurement and Information Systems, Budapest University of Technology and Economics, Magyar Tudósok krt. 2, H-1521 Budapest, Hungary.
Gyorgy BagdyDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.
John Francis William DeakinDivision of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Gabriella JuhaszDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.ORCID 0000-0002-5975-4267
Semmelweis University · HUBudapest University of Technology and Economics · HUKing's College London · GBUniversity of Manchester · GB

Funding

Hungarian Brain Research Program 2017-1.2.1-NKP-2017-00002Hungarian Brain Research Program KTIA_13_NAPA-II/14Hungarian Scientific Research Fund 119866Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Ministry for Innovation and Technology ÚNKP-20-4-II-SE-9Ministry for Innovation and Technology ÚNKP-20-5-BME-92Ministry for Innovation and Technology ÚNKP-21-4-II-SE-1Ministry for Innovation and Technology ÚNKP-21-5-BME-362National Development Agency KTIA_NAP_13-1-2013-0001National Development Agency KTIA_NAP_13-2-2015-0001National Research, Development and Innovation Office 2019-2.1.7-ERA-NET-2020-00005Sixth Framework Program of the European Union LSHM-CT-2004-503474Thematic Excellence Programme 2020-4.1.1.-TKP2020
6 · The paper itself

Abstract

Past-oriented rumination and future-oriented worry are two aspects of perseverative negative thinking related to the neuroticism endophenotype and associated with depression and anxiety. Our present aim was to investigate the genomic background of these two aspects of perseverative negative thinking within separate groups of individuals with suboptimal versus optimal folate intake. We conducted a genome-wide association study in the UK Biobank database (

Indexed as

Dietary SupplementsAdolescentAdultAgedAnxietyARNTL Transcription FactorsDepressionEatingEther-A-Go-Go Potassium ChannelsFemaleFolic AcidGenome-Wide Association StudyHumansMaleMiddle AgedNerve Tissue ProteinsARNTL Transcription FactorsBMAL1 protein, humanEther-A-Go-Go Potassium ChannelsFolic AcidKCNH3 protein, humanNerve Tissue Proteinsfolategene x diet interactionGWASneuroticismruminationworry

Identifiers

PMID34959947
PMCPMC8703428
OpenAlexW4200337783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.