ReviewNutrients2021
Calcium and Vitamin D Supplementation and Their Association with Kidney Stone Disease: A Narrative Review.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Pooled it
- Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.Nature communications · 2023Pooled it
- Causal effects of modifiable risk factors on kidney stones: a bidirectional mendelian randomization study.BMC medical genomics · 2023Pooled it
- Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events.Journal of pharmaceutical health care and sciences · 2026Article
- Association between sarcopenic obesity and kidney stones: evidence from a prospective cohort study on the UK Biobank.BMC public health · 2026Article
- Steroid hormones and nephrolithiasis: regulation of urine components metabolism and inflammation.Biology of sex differences · 2026Review
- Analysis of factors affecting the efficacy and stone clearance rate of super-mini PCNL (SMP) versus standard PCNL (sPCNL) in the treatment of different sizes of renal stones.International urology and nephrology · 2026Article
- Aldehyde Dehydrogenase 2 Gene Polymorphism and Alcohol Consumption Are Associated With Nephrolithiasis in a Chinese Population.Molecular genetics & genomic medicine · 2026Article
- The effect of geography and climatic factors on the hospitality burden due to kidney stones in Spain 1997-2022.Open research Europe · 2026Article
- Use of Vitamins and Supplements During Pregnancy and Their Association with Maternal and Birth Outcomes: A Prospective Cohort Study.Patient preference and adherence · 2026Article
- Association of insulin resistance indices with kidney stones and their recurrence in a non-diabetic population: an analysis based on NHANES data from 2007-2018.Renal failure · 2025Article
- The Role of Diet in Kidney Stone Pathogenesis and Prevention.Current urology reports · 2025Review
- Analysis of risk factors for kidney stones in patients with hyperuricemia: a cross-sectional study based on NHANES.Translational andrology and urology · 2025Article
- The prevalence of vitamin D deficiency and insufficiency in calcium oxalate stone formers in Ontario, Canada, and the impact of vitamin D supplementation.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025Article
- Vitamin D Metabolism and the Risk of Renal Stones: A Focus on PHPT.Metabolites · 2025Review
- Article
- Dysregulated lipid metabolism in kidney stone pathogenesis: a literature review of mechanistic insights and therapeutic implications.BMC urology · 2025Review
- Article
- Whey Protein Nutrition in Sports: Action Mechanisms and Gaps in Research.Current nutrition reports · 2025Review
- Associations between clinical, biochemical, and nutritional factors in kidney stone formation and recurrence.Urolithiasis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidney stone disease is a multifactorial condition influenced by both genetic predisposition and environmental factors such as lifestyle and dietary habits. Although different monogenic polymorphisms have been proposed as playing a causal role for calcium nephrolithiasis, the prevalence of these mutations in the general population and their complete pathogenetic pathway is yet to be determined. General dietary advice for kidney stone formers includes elevated fluid intake, dietary restriction of sodium and animal proteins, avoidance of a low calcium diet, maintenance of a normal body mass index, and elevated intake of vegetables and fibers. Thus, balanced calcium consumption protects against the risk for kidney stones by reducing intestinal oxalate availability and its urinary excretion. However, calcium supplementation given between meals might increase urinary calcium excretion without the beneficial effect on oxalate. In kidney stone formers, circulating active vitamin D has been found to be increased, whereas higher plasma 25-hydroxycholecalciferol seems to be present only in hypercalciuric patients. The association between nutritional vitamin D supplements and the risk for stone formation is currently not completely understood. However, taken together, available evidence might suggest that vitamin D administration worsens the risk for stone formation in patients predisposed to hypercalciuria. In this review, we analyzed and discussed available literature on the effect of calcium and vitamin D supplementation on the risk for kidney stone formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.