ArticleNutrients2021
Hemp Seeds in Post-Arthroplasty Rehabilitation: A Pilot Clinical Study and an In Vitro Investigation.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Ancient grain flour consumption as a novel therapeutic approach for irritable bowel syndrome.European journal of nutrition · 2025Trial
- Growth Performance and Carcass Traits in Purebred Apulo-Calabrese and Crossbred (Apulo-Calabrese × Goland) Pigs Fed Linseed and Grape Pomace Powder Naturally Rich in Antioxidants.Veterinary sciences · 2026Article
- Surface prereacted glass-ionomer particles incorporated into resin composites promote biocompatibility for restoration of subgingival dental defects.Materials today. Bio · 2025Article
- Zibibbo Grape Seeds' Polyphenolic Profile: Effects on Bone Turnover and Metabolism.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Assessment of MediterraneanPlants (Basel, Switzerland) · 2023Article
- The Role of Hemp (Foods (Basel, Switzerland) · 2023Review
- Hemp Flour Particle Size Affects the Quality and Nutritional Profile of the Enriched Functional Pasta.Foods (Basel, Switzerland) · 2023Article
- Effects of a Functional Ice Cream Enriched with Milk Proteins on Bone Metabolism: A Feasibility Clinical Study and In Vitro Investigation.Nutrients · 2023Article
- A comprehensive analysis of biomarkers associated with synovitis and chondrocyte apoptosis in osteoarthritis.Frontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis is a type of degenerative joint disease that results from the breakdown of joint cartilage and underlying bone. Due to their antioxidants and anti-inflammatory action, the phytochemical constituents of many vegetable varieties could represent a new frontier for the treatment of patients with Osteoarthritis and are still being explored. The aim of this pilot human study was to investigate the effects of pasta enriched with hemp seed flour on osteoarticular pain and bone formation markers in patients in post-arthroplasty rehabilitation. Another purpose was to evaluate the effect of hemp seed extract on bone metabolism, in vitro. A pilot, controlled, clinical study was conducted to verify the feasibility of pain symptom reduction in patients with Osteoarthritis undergoing arthroplasty surgery. We also investigated the effect of hemp seed extract on the Wnt/β-catenin and ERK1/2 pathways, alkaline phosphatase, RANKL, RUNX-2, osteocalcin, and COL1A on Saos-2. After 6 weeks, the consumption of hemp seed pasta led to greater pain relief compared to the regular pasta control group (-2.9 ± 1.3 cm vs. -1.3 ± 1.3 cm;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.