Evidence map›Paper›PMID 34959853›Full record

ArticleNutrients2021

Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy.

Rebekah Nixon, Ting Hin Richard Ip, Benjamin Jenkins, Ping K Yip, Paul Clarke, Vennila Ponnusamy, Adina T Michael-Titus, Albert Koulman, Divyen K Shah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Rebekah NixonThe Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK.
Ting Hin Richard IpThe Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK.
Benjamin JenkinsNIHR Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-0038-9709
Ping K YipCentre for Neuroscience, Surgery and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Paul ClarkeNeonatal Unit, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich NR4 7UY, UK.ORCID 0000-0001-6203-7632
Vennila PonnusamyAshford and St. Peter's Hospitals NHS Foundation Trust, Chertsey KT16 0PZ, UK.
Adina T Michael-TitusCentre for Neuroscience, Surgery and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Albert KoulmanNIHR Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0001-9998-051X
Divyen K ShahThe Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK.
Queen Mary University of London · GBUniversity of Cambridge · GBAshford and St Peter's Hospitals NHS Foundation Trust · GBUniversity of East Anglia · GB

Funding

Barts Charity N/A
6 · The paper itself

Abstract

Hypoxic-ischemic encephalopathy (HIE) is associated with perinatal brain injury, which may lead to disability or death. As the brain is a lipid-rich organ, various lipid species can be significantly impacted by HIE and these correlate with specific changes to the lipidomic profile in the circulation. Objective: To investigate the peripheral blood lipidomic signature in dried blood spots (DBS) from newborns with HIE. Using univariate analysis, multivariate analysis and sPLS-DA modelling, we show that newborns with moderate-severe HIE (

Indexed as

Hypothermia, InducedDried Blood Spot TestingFemaleHumansHypoxia-Ischemia, BrainInfant, NewbornLipidomicsLipidsMaleLipidsbraindried blood spothypoxic-ischemic encephalopathylipidomelipidsnewbornnutritiontherapeutic hypothermia

Identifiers

PMID34959853
PMCPMC8703828
OpenAlexW3214817859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.