Evidence map›Paper›PMID 34959842›Full record

ArticleNutrients2021

Unhealthy Lifestyle, Genetics and Risk of Cardiovascular Disease and Mortality in 76,958 Individuals from the UK Biobank Cohort Study.

Katherine M Livingstone, Gavin Abbott, Joey Ward, Steven J Bowe

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Katherine M LivingstoneInstitute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC 3220, Australia.ORCID 0000-0002-9682-7541
Gavin AbbottInstitute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC 3220, Australia.ORCID 0000-0003-4014-0705
Joey WardInstitute of Health and Wellbeing, University of Glasgow, Glasgow G12 8RZ, UK.
Steven J BoweDeakin Biostatistics Unit, Deakin University, Geelong, VIC 3220, Australia.
Deakin University · AUUniversity of Glasgow · GB

Funding

British Heart Foundation CH/1996001/9454Lister Prize Fellowship 173096Medical Research Council MC_PC_17228Medical Research Council MC_QA137853National Health and Medical Research Council APP1173803
6 · The paper itself

Abstract

To examine associations of unhealthy lifestyle and genetics with risk of all-cause mortality, cardiovascular disease (CVD) mortality, myocardial infarction (MI) and stroke. We used data on 76,958 adults from the UK Biobank prospective cohort study. Favourable lifestyle included no overweight/obesity, not smoking, physical activity, not sedentary, healthy diet and adequate sleep. A Polygenic Risk Score (PRS) was derived using 300 CVD-related single nucleotide polymorphisms. Cox proportional hazard ratios (HR) were used to model effects of lifestyle and PRS on risk of CVD and all-cause mortality, stroke and MI. New CVD (

Indexed as

Life StyleAdultAgedBiological Specimen BanksCardiometabolic Risk FactorsCardiovascular DiseasesFemaleFollow-Up StudiesHealth BehaviorHumansMaleMiddle AgedMyocardial InfarctionPolymorphism, Single NucleotideProportional Hazards ModelsProspective Studiescardiovascular diseasegenetic riskhealthy lifestylemortalitymyocardial infarctionstroke

Identifiers

PMID34959842
PMCPMC8707428
OpenAlexW3215464165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.