Evidence map›Paper›PMID 34959831›Full record

ArticleNutrients2021

Effect of Dairy Matrix on the Postprandial Blood Metabolome.

Rebekka Thøgersen, Kristian Leth Egsgaard, Louise Kjølbæk, Klaus Juhl Jensen, Arne Astrup, Marianne Hammershøj, Anne Raben, Hanne Christine Bertram

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rebekka ThøgersenDepartment of Food Science, Aarhus University, Agro Food Park 48, DK-8200 Aarhus, Denmark.
Kristian Leth EgsgaardDepartment of Food Science, Aarhus University, Agro Food Park 48, DK-8200 Aarhus, Denmark.
Louise KjølbækDepartment of Nutrition, Exercise and Sports, University of Copenhagen, DK-1958 Frederiksberg, Denmark.ORCID 0000-0003-4310-9332
Klaus Juhl JensenArla Foods Amba, DK-8200 Aarhus, Denmark.
Arne AstrupDepartment of Nutrition, Exercise and Sports, University of Copenhagen, DK-1958 Frederiksberg, Denmark.ORCID 0000-0001-8968-8996
Marianne HammershøjDepartment of Food Science, Aarhus University, Agro Food Park 48, DK-8200 Aarhus, Denmark.ORCID 0000-0001-9297-6526
Anne RabenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, DK-1958 Frederiksberg, Denmark.ORCID 0000-0001-5229-4491
Hanne Christine BertramDepartment of Food Science, Aarhus University, Agro Food Park 48, DK-8200 Aarhus, Denmark.ORCID 0000-0002-1882-5321
Aarhus University · DKUniversity of Copenhagen · DKArla Foods (Denmark) · DK

Funding

Arla Food for Health
6 · The paper itself

Abstract

This study investigated the postprandial plasma metabolome following consumption of four dairy matrices different in texture and structure: cheddar cheese (Cheese), homogenized cheddar cheese (Hom. Cheese), and micellar casein isolate (MCI) with cream (MCI Drink) or a MCI Gel. An acute, randomized, crossover trial in male participants (n = 25) with four test days was conducted. Blood samples were collected during an 8-h postprandial period after consumption of a meal similar in micro- and macronutrients containing one of the four dairy matrices, and the metabolome was analyzed using nuclear magnetic resonance (NMR) spectroscopy. A liquid dairy matrix (MCI Drink) resulted in a faster absorption of amino acids compared to products, representing either a semi-solid (MCI Gel and Hom. Cheese) or solid (Cheese) dairy matrix. For the MCI Gel, plasma concentration of acetic acid and formic acid increased approximately 2 h following consumption, while 3-hydroxybyturate and acetoacetic acid increased approximately 6 h after consumption. The structure and texture of the dairy matrix affected the postprandial absorption of amino acids, as revealed by the plasma metabolome. Our study furthermore pointed at endogenous effects associated with consumption of dairy products containing glucono-δ-lactone.

Indexed as

AdultAmino AcidsCaseinsCheeseDairy ProductsGastrointestinal AbsorptionGluconatesHumansLactonesMagnetic Resonance SpectroscopyMaleMealsMetabolomePostprandial PeriodYoung AdultAmino Acidsbeta-glucono-1,5-lactoneCaseinsGluconatesLactonesamino acid absorptioncheesefood structureglucono-δ-lactoneNMR metabolomics

Identifiers

PMID34959831
PMCPMC8709269
OpenAlexW3215886290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.