Evidence map›Paper›PMID 34959807›Full record

ArticleNutrients2021

Human Milk Oligosaccharides in Cord Blood Are Altered in Gestational Diabetes and Stimulate Feto-Placental Angiogenesis In Vitro.

Denise Hoch, Waltraud Brandl, Jasmin Strutz, Harald C Köfeler, Mireille N M van Poppel, Lars Bode, Ursula Hiden, Gernot Desoye, Evelyn Jantscher-Krenn

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Observational
  3. Downregulation of the Long Non-Coding RNALife (Basel, Switzerland) · 2026
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Denise HochDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-7169-7007
Waltraud BrandlDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.
Jasmin StrutzDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-6138-7566
Harald C KöfelerCore Facility Mass Spectrometry, Center for Medical Research, Medical University of Graz, 8010 Graz, Austria.
Mireille N M van PoppelBioTechMed Graz, 8010 Graz, Austria.ORCID 0000-0001-5694-4324
Lars BodeDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (LRF MoMI CoRE), University of California San Diego, La Jolla, CA 92093, USA.
Ursula HidenDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.
Gernot DesoyeDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-5715-3230
Evelyn Jantscher-KrennDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-3568-891X
Medical University of Graz · ATUniversity of California San Diego · USUniversity of Graz · AT

Funding

European Commission 627056FWF Austrian Science Fund KLI 784National Bank of Austria 16927
6 · The paper itself

Abstract

(1) Background: Human milk oligosaccharides (HMOs) are present in maternal serum during pregnancy and their composition is altered in gestational diabetes (GDM). HMOs are also in fetal cord blood and in contact with the feto-placental endothelium, potentially affecting its functions, such as angiogenesis. We hypothesized that cord blood HMOs are changed in GDM and contribute to increased feto-placental angiogenesis, hallmark of GDM. (2) Methods: Using HPLC, we quantified HMOs in cord blood of women with normal glucose tolerance (NGT,

Indexed as

Angiogenesis Inducing AgentsCell ProliferationChromatography, High Pressure LiquidDiabetes, GestationalEndothelial CellsFemaleFetal BloodHumansLactoseMilk, HumanOligosaccharidesPlacentaPlacental CirculationPregnancy3'-sialyllactoseAngiogenesis Inducing AgentsLactoseOligosaccharides3′-sialyllactoseangiogenesiscord bloodfibrin tube formation assaygestational diabetes mellitushuman milk oligosaccharidesplacentapregnancyspheroid sprouting assaytube formation

Identifiers

PMID34959807
PMCPMC8705424
OpenAlexW3217212291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.