Evidence map›Paper›PMID 34959790›Full record

ArticleNutrients2021

Silymarin Dehydroflavonolignans Chelate Zinc and Partially Inhibit Alcohol Dehydrogenase.

Václav Tvrdý, Marcel Hrubša, Eduard Jirkovský, David Biedermann, Michal Kutý, Kateřina Valentová, Vladimír Křen, Přemysl Mladěnka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. ExaminingFrontiers in toxicology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Václav TvrdýDepartment of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.ORCID 0000-0001-7116-0333
Marcel HrubšaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.ORCID 0000-0002-9958-9366
Eduard JirkovskýDepartment of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
David BiedermannLaboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.ORCID 0000-0001-6726-9301
Michal KutýDepartment of Chemistry, Faculty of Science, University of South Bohemia in Ceske Budejovice, Branisovska 1760, 370 05 Ceske Budejovice, Czech Republic.
Kateřina ValentováLaboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.ORCID 0000-0002-7714-5350
Vladimír KřenLaboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.ORCID 0000-0002-1091-4020
Přemysl MladěnkaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.ORCID 0000-0002-6076-6900
Charles University · CZCzech Academy of Sciences · CZUniversity of South Bohemia in České Budějovice · CZ

Funding

Charles University SVV 2020/260 414Czech Science Foundation (No. 18-00121S).Ministry of Education, Youth and Sport, Czech Republic CZ.02.1.01/0.0/0.0/16_017/0002682Ministry of Education, Youth and Sport, Czech Republic CZ.02.1.01/0.0/0.0/16_019/0000841
6 · The paper itself

Abstract

Silymarin is known for its hepatoprotective effects. Although there is solid evidence for its protective effects against

Indexed as

Alcohol DehydrogenaseAnimalsChelating AgentsFlavonolignansGlutamate DehydrogenaseHorsesSilybinSilymarinYeastsZincAlcohol DehydrogenaseChelating AgentsFlavonolignansGlutamate DehydrogenaseSilybinSilymarinZincalcohol dehydrogenasechelationdehydrosilybindockingflavonolignansglutamate dehydrogenasesilybinzinc

Identifiers

PMID34959790
PMCPMC8708252
OpenAlexW3216683796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.