Observational studyNutrients2021
Impact of Oropharyngeal Administration of Colostrum in Preterm Newborns' Oral Microbiome.
Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- [Effect of colostrum oral immune therapy on the the clinical outcomes in very low birth weight infants: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Pooled it
- Intervention Effect of Oropharyngeal Administration of Colostrum in Preterm Infants: A Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Investigating the effect of oropharyngeal colostrum in the prevention of late-onset sepsis in preterm infants: a randomized controlled trial.Scientific reports · 2025Trial
- Factors Influencing the Colostrum's Microbiota: A Systematic Review of the Literature.Children (Basel, Switzerland) · 2025Review
- Impact of colostrum oropharyngeal immunotherapy on postnatal growth in preterm infants based on early gut microbiota-host interaction patterns: protocol for a randomized controlled trial.International breastfeeding journal · 2025Article
- Article
- Influence of oropharyngeal therapy with mother's own milk on the microbiome and metabolome of very preterm infants: a pilot study.Frontiers in nutrition · 2025Article
- A Scoping Review of the Oral Microbiome in Preterm Infants.American journal of perinatology · 2024Article
- Article
- Article
- Neonatal Microbiome: Is it Still Beneficial?Endocrine, metabolic & immune disorders drug targets · 2024Article
- Oropharyngeal administration of colostrum targeting gut microbiota and metabolites in very preterm infants: protocol for a multicenter randomized controlled trial.BMC pediatrics · 2023Article
- Colostrum and Preterm Babies: A Systematic Review.Cureus · 2023Review
- Article
- Impact of breastfeeding and other early-life factors on the development of the oral microbiome.Frontiers in microbiology · 2023Review
- Association of Prematurity and Low Birth Weight with Gestational Exposure to PMInternational journal of environmental research and public health · 2022Article
- Oral Microbiota during Childhood and Its Role in Chemotherapy-Induced Oral Mucositis in Children with Cancer.Pathogens (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The initial colonization of the human microbiota is of paramount importance. In this context, the oropharyngeal administration of colostrum is a safe, viable, and well-tolerated practice even by the smallest preterm infants. Therefore, this study evaluated the effects of oropharyngeal administration of colostrum on the establishment of preterm infants' oral microbiota. A longitudinal observational study was carried out with 20 premature neonates, divided into two groups: one receiving the protocol (Oropharyngeal Administration of Colostrum; OAC) and the other one receiving Standard Caare (SC). Saliva samples were collected from the newborns weekly during the study period (from the day of birth until the 21st day of life) for analysis of oral microbiota through 16S rRNA gene sequencing. We observed that the colonization of the oral microbiota of preterm newborns preseanted a higher relative abundance of
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.