Evidence map›Paper›PMID 34959674›Full record

ReviewPharmaceuticals (Basel, Switzerland)2021

An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms.

Jinyun Chen, Sunyan Lv, Jia Liu, Yanlei Yu, Hong Wang, Huawei Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Anticancer Activity ofBiomolecules · 2025
    Article
  5. Review
  6. Review
  7. Synthesis of Oxazoles Containing CFMolecules (Basel, Switzerland) · 2024
    Article
  8. Article
  9. Responses of the MacroalgaMarine drugs · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jinyun ChenSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0003-0711-1988
Sunyan LvSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Jia LiuSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0002-6714-8048
Yanlei YuCollaborative Innovation Center of Green Pharmaceutics of Delta Yangzi Region, Zhejiang University of Technology, Hangzhou 310014, China.
Hong WangSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0003-0058-060X
Huawei ZhangSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0002-2430-3845
Zhejiang University of Technology · CNZhejiang Marine Fisheries Research Institute · CN

Funding

Fundamental Research Fund for the Provincial Universities of Zhejiang (China) RF-C2019002National Key R&D Program of China 2018YFC0311004National Natural Science Foundation of China 41776139
6 · The paper itself

Abstract

1,3-Oxazole chemicals are a unique class of five-membered monocyclic heteroarenes, containing a nitrogen atom and an oxygen. These alkaloids have attracted extensive attention from medicinal chemists and pharmacologists owing to their diverse arrays of chemical structures and biological activities, and a series of 1,3-oxazole derivatives has been developed into therapeutic agents (e.g., almoxatone, befloxatone, cabotegravir, delpazolid, fenpipalone, haloxazolam, inavolisib). A growing amount of evidence indicates that marine organisms are one of important sources of 1,3-oxazole-containing alkaloids. To improve our knowledge regarding these marine-derived substances, as many as 285 compounds are summarized in this review, which, for the first time, highlights their sources, structural features and biological properties, as well as their biosynthesis and chemical synthesis. Perspective for the future discovery of new 1,3-oxazole compounds from marine organisms is also provided.

Indexed as

1,3-oxazolealkaloidbioactive propertymarine natural productmarine organismmarine spongesymbiotic microorganism

Identifiers

PMID34959674
PMCPMC8706051
OpenAlexW4200619437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.