Evidence map›Paper›PMID 34959640›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

A Large Sample Retrospective Study on the Distinction of Voriconazole Concentration in Asian Patients from Different Clinical Departments.

Yichang Zhao, Chenlin Xiao, Jingjing Hou, Jiamin Wu, Yiwen Xiao, Bikui Zhang, Indy Sandaradura, Miao Yan

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yichang ZhaoDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.ORCID 0000-0002-9651-4457
Chenlin XiaoDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Jingjing HouDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Jiamin WuDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Yiwen XiaoDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Bikui ZhangDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Indy SandaraduraSchool of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Miao YanDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China.ORCID 0000-0002-3582-8305
Central South University · CNWestmead Hospital · AU

Funding

The Hunan Pharmaceutical Association of China HMA202001002
6 · The paper itself

Abstract

Voriconazole (VRZ) is widely used to prevent and treat invasive fungal infections; however, there are a few studies examining the variability and influencing the factors of VRZ plasma concentrations across different clinical departments. This study aimed to evaluate distinction of VRZ concentrations in different clinical departments and provide a reference for its reasonable use. From 1 May 2014 to 31 December 2020, VRZ standard rates and factors affecting the VRZ trough concentration were analyzed, and a multiple linear regression model was constructed. The standard rates of VRZ in most departments were above 60%. A total of 676 patients with 1212 VRZ trough concentrations using a dosing regimen of 200 mg q12h from seven departments were enrolled in the correlation analysis. The concentration distribution varied significantly among different departments (

Indexed as

different departmentsdifferent populationtherapeutic drug monitoringtrough concentrationvoriconazole

Identifiers

PMID34959640
PMCPMC8705093
OpenAlexW3217761185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.