Evidence map›Paper›PMID 34959590›Full record

ReviewPathogens (Basel, Switzerland)2021

Effects of Cigarette Smoking on Influenza Virus/Host Interplay.

Jerald Chavez, Rong Hai

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jerald ChavezDepartment of Microbiology and Plant Pathology, University of California-Riverside, Riverside, CA 92521, USA.
Rong HaiDepartment of Microbiology and Plant Pathology, University of California-Riverside, Riverside, CA 92521, USA.
University of California, Riverside · US

Funding

Mechanistic Insights into flavivirus NS5-mediated STAT2 SuppressionR01AI153419 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HAI, RONG · 2021 to 2025
$1.9M
Mechanistic understanding and inhibition of Zika NS5 proteinR21AI147057 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HAI, RONG, SONG, JIKUI · 2019 to 2020
$739k
National Institute of Allergy and Infectious Diseases 1R21AI147057National Institute of Allergy and Infectious Diseases R01AI153419University of California, Riverside Tobacco Related Disease Research Program (TRDRP, T30DT1060)
6 · The paper itself

Abstract

Cigarette smoking has been shown to increase the risk of respiratory infection, resulting in the exacerbation of infectious disease outcomes. Influenza viruses are a major respiratory viral pathogen, which are responsible for yearly epidemics that result in between 20,000 and 50,000 deaths in the US alone. However, there are limited general summaries on the impact of cigarette smoking on influenza pathogenic outcomes. Here, we will provide a systematic summarization of the current understanding of the interplay of smoking and influenza viral infection with a focus on examining how cigarette smoking affects innate and adaptive immune responses, inflammation levels, tissues that contribute to systemic chronic inflammation, and how this affects influenza A virus (IAV) disease outcomes. This summarization will: (1) help to clarify the conflict in the reports on viral pathogenicity; (2) fill knowledge gaps regarding critical anti-viral defenses such as antibody responses to IAV; and (3) provide an updated understanding of the underlying mechanism behind how cigarette smoking influences IAV pathogenicity.

Indexed as

host responseinfluenza virussmoking

Identifiers

PMID34959590
PMCPMC8704216
OpenAlexW4200254834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.