Evidence map›Paper›PMID 34959544›Full record

ArticlePathogens (Basel, Switzerland)2021

Immunological and Genetic Investigation of SARS-CoV-2 Reinfection in an Otherwise Healthy, Young Marine Recruit.

Andrew G Letizia, Catherine E Arnold, Bishwo N Adhikari, Logan J Voegtly, Lindsay Glang, Gregory K Rice, Carl W Goforth, Megan A Schilling, Dawn L Weir, Francisco Malagon and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andrew G LetiziaInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.ORCID 0000-0002-7361-5917
Catherine E ArnoldDefense Threat Reduction Agency, Fort Belvoir, VA 22060, USA.ORCID 0000-0002-1635-4941
Bishwo N AdhikariDefense Threat Reduction Agency, Fort Belvoir, VA 22060, USA.ORCID 0000-0003-4840-9609
Logan J VoegtlyGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.
Lindsay GlangGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.
Gregory K RiceGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.
Carl W GoforthInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.
Megan A SchillingInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.
Dawn L WeirInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.ORCID 0000-0002-5653-8905
Francisco MalagonGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.
Irene RamosDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-0223-0120
Sindhu VangetiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-3404-6878
Ana S Gonzalez-ReicheDepartment of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-3583-4497
Regina Z CerGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.
Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Harm van BakelDepartment of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology at Mount Sinai, New York, NY 10029, USA.
Kimberly A Bishop-LillyGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.

Funding

Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Defense Advanced Research Projects Agency N660019C4022Defense Health Agency 9700130NIH HHS S10 OD026880
6 · The paper itself

Abstract

We used epidemiologic and viral genetic information to identify a case of likely reinfection in an otherwise healthy, young Marine recruit enrolled in the prospective, longitudinal COVID-19 Health Action Response for Marines (CHARM) study, and we paired these findings with serological studies. This participant had a positive RT-PCR to SARS-CoV-2 upon routine sampling on study day 7, although he was asymptomatic at that time. He cleared the infection within seven days. On study day 46, he had developed symptoms consistent with COVID-19 and tested positive by RT-PCR for SARS-CoV-2 again. Viral whole genome sequencing was conducted from nares swabs at multiple time points. The day 7 sample was determined to be lineage B.1.340, whereas both the day 46 and day 49 samples were B.1.1. The first positive result for anti-SARS-CoV-2 IgM serology was collected on day 49 and for IgG on day 91. This case appears most consistent with a reinfection event. Our investigation into this case is unique in that we compared sequence data from more than just paired specimens, and we also assayed for immune response after both the initial infection and the later reinfection. These data demonstrate that individuals who have experienced an infection with SARS-CoV-2 may fail to generate effective or long-lasting immunity, similar to endemic human beta coronaviruses.

Indexed as

CHARMCOVID-19genomicsmarinesnext generation sequencing (NGS)reinfectionSARS-CoV-2

Identifiers

PMID34959544
PMCPMC8709254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.