ArticlePharmaceutics2021
Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System.
Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Minimally Invasive Endovascular Administration for Targeted PLGA Nanoparticles Delivery to Brain, Salivary Glands, Kidney and Lower Limbs.Pharmaceutics · 2026Article
- Brain neurons internalise polymeric micron-sized capsules: Insights fromMaterials today. Bio · 2025Article
- Large-scale super-resolution optoacoustic imaging facilitated by FeNP/ICG-loaded coreless polyelectrolyte microcapsules.Theranostics · 2025Article
- The Buffer Capacity of Polyelectrolyte Microcapsules Depends on the Type of Template.Polymers · 2024Article
- Characterization of Polyallylamine/Polystyrene Sulfonate Polyelectrolyte Microcapsules Formed on Solid Cores: Morphology.Polymers · 2024Review
- Microfluidically Assisted Synthesis of Calcium Carbonate Submicron Particles with Improved Loading Properties.Micromachines · 2023Article
- Magnetic UiO-66-NHACS omega · 2023Article
- Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy.Pharmaceutics · 2023Review
- Doxorubicin-Loaded Polyelectrolyte Multilayer Capsules Modified with Antitumor DR5-Specific TRAIL Variant for Targeted Drug Delivery to Tumor Cells.Nanomaterials (Basel, Switzerland) · 2023Article
- Targeted Therapy for Glomerulonephritis Using Arterial Delivery of Encapsulated Etanercept.International journal of molecular sciences · 2023Article
- The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow.Molecules (Basel, Switzerland) · 2022Article
- Renal Artery Catheterization for Microcapsules' Targeted Delivery to the Mouse Kidney.Pharmaceutics · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Drug carriers based on polyelectrolyte microcapsules remotely controlled with an external magnetic field are a promising drug delivery system. However, the influence of capsule parameters on microcapsules' behavior in vivo is still ambiguous and requires additional study. Here, we discuss how the processes occurring in the blood flow influence the circulation time of magnetic polyelectrolyte microcapsules in mouse blood after injection into the blood circulatory system and their interaction with different blood components, such as WBCs and RBCs. The investigation of microcapsules ranging in diameter 1-5.5 μm allowed us to reveal the dynamics of their filtration by vital organs, cytotoxicity, and hemotoxicity, which is dependent on their size, alongside the efficiency of their interaction with the magnetic field. Our results show that small capsules have a long circulation time and do not affect blood cells. In contrast, the injection of large 5.5 μm microcapsules leads to fast filtration from the blood flow, induces the inhibition of macrophage cell line proliferation after 48 h, and causes an increase in hemolysis, depending on the carrier concentration. The obtained results reveal the possible directions of fine-tuning microcapsule parameters, maximizing capsule payload without the side effects for the blood flow or the blood cells.
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Registered trials
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