Evidence map›Paper›PMID 34959400›Full record

ArticlePharmaceutics2021

Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium

Rosa Giugliano, Carmine Buonocore, Carla Zannella, Annalisa Chianese, Fortunato Palma Esposito, Pietro Tedesco, Anna De Filippis, Massimiliano Galdiero, Gianluigi Franci, Donatella de Pascale

Abstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Journal of virology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Genetically engineeredFrontiers in microbiology · 2025
    Article
  10. Review
  11. The FirstViruses · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Viruses · 2023
    Article
  18. Marine drugs · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rosa GiuglianoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-9923-3194
Carmine BuonocoreDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-8327-954X
Carla ZannellaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-7991-8700
Annalisa ChianeseDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1648-4519
Fortunato Palma EspositoDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-3768-4712
Pietro TedescoDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0003-0165-5386
Anna De FilippisDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-0395-7962
Massimiliano GaldieroDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1576-6290
Gianluigi FranciDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0003-3321-4331
Donatella de PascaleDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.

Funding

H2020-FNR-11-2020: SECRETED 101000794PRIN 2017 "Natural and pharmacological inhibition of the early phase of viral replication (VirSudNet)" 2017M8R7N9
6 · The paper itself

Abstract

Emerging and re-emerging viruses represent a serious threat to human health at a global level. In particular, enveloped viruses are one of the main causes of viral outbreaks, as recently demonstrated by SARS-CoV-2. An effective strategy to counteract these viruses could be to target the envelope by using surface-active compounds. Rhamnolipids (RLs) are microbial biosurfactants displaying a wide range of bioactivities, such as antibacterial, antifungal and antibiofilm, among others. Being of microbial origin, they are environmentally-friendly, biodegradable, and less toxic than synthetic surfactants. In this work, we explored the antiviral activity of the rhamnolipids mixture (M15RL) produced by the Antarctic bacteria

Indexed as

Antarctic bacteriaantiviralcoronavirusenveloped virusherpesmicrobial biosurfactantsrhamnolipidsSARS-CoV-2TEM

Identifiers

PMID34959400
PMCPMC8704987

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.