Evidence map›Paper›PMID 34959385›Full record

ArticlePharmaceutics2021

Evaluation of Ruthenium-Based Assemblies as Carriers of Photosensitizers to Treat Rheumatoid Arthritis by Photodynamic Therapy.

Manuel Gallardo-Villagrán, Lucie Paulus, Jean-Louis Charissoux, Sylvain Sutour, Pascale Vergne-Salle, David Yannick Leger, Bertrand Liagre, Bruno Therrien

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Manuel Gallardo-VillagránInstitut de Chimie, Université de Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland.ORCID 0000-0001-8500-6185
Lucie PaulusLaboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges, 87025 Limoges, France.
Jean-Louis CharissouxService d'Orthopédie-Traumatologie, CHRU Dupuytren, 2 Avenue Martin Luther King, CEDEX, 87042 Limoges, France.
Sylvain SutourNeuchâtel Platform for Analytical Chemistry (NPAC), University of Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland.ORCID 0000-0001-9676-7123
Pascale Vergne-SalleService de Rhumatologie, CHRU Dupuytren 2, 16 rue Bernard Descottes, CEDEX, 87042 Limoges, France.
David Yannick LegerLaboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges, 87025 Limoges, France.
Bertrand LiagreLaboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges, 87025 Limoges, France.ORCID 0000-0003-4148-2598
Bruno TherrienInstitut de Chimie, Université de Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland.ORCID 0000-0002-0388-2745
Université de Limoges · FRUniversity of Neuchâtel · CHHôpital Dupuytren · FR

Funding

European Union's Horizon 2020 under the Marie Sklodowska-Curie grant agreement no. 764837
6 · The paper itself

Abstract

For the first time, ruthenium-based assemblies have been used as carriers for photosensitizers in the treatment of rheumatoid arthritis by photodynamic therapy (PDT). These metallacages are totally soluble in physiological media and can transport photosensitizers (PS) in their cavity. After an incubation period, the PS is released in the cytoplasm and irradiation can take place. This strategy allows photosensitizers with low or null solubility in biological media to be evaluated as PDT agents in rheumatoid arthritis. The systems in which 21

Indexed as

arene ruthenium complexesCOX-2drug deliveryhost–guest systemphotodynamic therapyphotosensitizerrheumatoid arthritis

Identifiers

PMID34959385
PMCPMC8706357
OpenAlexW4200006764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.