Evidence map›Paper›PMID 34959354›Full record

ArticlePharmaceutics2021

Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer.

Nahid S Awad, Mohamed Haider, Vinod Paul, Nour M AlSawaftah, Jayalakshmi Jagal, Renu Pasricha, Ghaleb A Husseini

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

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  9. Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Nahid S AwadDepartment of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Mohamed HaiderDepartment of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0000-0003-3150-9275
Vinod PaulDepartment of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Nour M AlSawaftahDepartment of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Jayalakshmi JagalResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Renu PasrichaCore Technology Platforms Operations, New York University Abu Dhabi, Abu Dhabi P.O. Box 129188, United Arab Emirates.
Ghaleb A HusseiniDepartment of Chemical Engineering, Collage of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.ORCID 0000-0002-7244-3105
American University of Sharjah · AECairo University · EGNew York University Abu Dhabi · AEUniversity of Sharjah · AE

Funding

Aljalila foundation (Grant number AJF201777)American University of Sharjah Faculty Research Grants (FRG20-L-48, and eFRG18-BBRCEN-03Sheikh Hamdan Award for Medical Sciences MRG-57- 2019-2020
6 · The paper itself

Abstract

Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydrophilic graphene quantum dots and triggered their release with ultrasound with the goal of developing a safer and well-controlled modality to deliver fluorescent markers to tumors. Our results confirmed the successful encapsulation of the QDs inside the core of the liposomes and showed no effect on the size or stability of the prepared liposomes. Our results also showed that low-frequency ultrasound is an effective method to release QDs encapsulated inside the liposomes in a spatially and temporally controlled manner to ensure the effective delivery of QDs to tumors while reducing their systemic toxicity.

Indexed as

controlled releaseliposomeslow-frequency ultrasoundquantum dots

Identifiers

PMID34959354
PMCPMC8705306
OpenAlexW4200531120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.