Evidence map›Paper›PMID 34959157›Full record

ArticleComputer methods and programs in biomedicine2022

EEG phase-amplitude coupling to stratify encephalopathy severity in the developing brain.

Xinlong Wang, Hanli Liu, Srinivas Kota, Yudhajit Das, Yulun Liu, Rong Zhang, Lina Chalak

Abstract read
In one paragraph

Article in Computer methods and programs in biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinlong WangDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, United States.
Hanli LiuDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, United States.
Srinivas KotaDepartment of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Yudhajit DasDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, United States.
Yulun LiuDepartment of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Rong ZhangDepartments of Internal Medicine and Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Lina ChalakDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address: Lina.chalak@utsouthwestern.edu.

Funding

A Novel Wavelet Neurovascular Bundle for Real Time Detection of Injury in Neonatal EncephalopathyR01NS102617 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LINA F CHALAK · 2017 to 2026
$4.0M
NINDS NIH HHS R01 NS102617
6 · The paper itself

Abstract

backgroundNeonatal hypoxic ischemic encephalopathy (HIE) is difficult to classify within the narrow therapeutic window of hypothermia. Neurophysiological biomarkers are needed for timely differentiation of encephalopathy severity within the short therapeutic window for initiation of hypothermia therapy.

methodsA novel analysis of mean Phase Amplitude Coupling index, PAC

results38 newborns with different HIE grades were enrolled in the first 6 h of life. Threshold PAC

conclusionPAC is a promising biomarker to identify mild from higher severity of HIE after birth.

Indexed as

Hypothermia, InducedHypoxia-Ischemia, BrainBrainElectroencephalographyHumansInfant, NewbornROC CurveEEGHypoxic ischemia encephalopathy biomarkersModified Sarnat ScoreNeonatal hypoxic ischemia encephalopathyNeural oscillation synchronyPhase amplitude coupling

Identifiers

PMID34959157
PMCPMC11614140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.