Evidence map›Paper›PMID 34959133›Full record

ArticleEBioMedicine2022

Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury: A CENTER-TBI study.

Daniel P Whitehouse, Miguel Monteiro, Endre Czeiter, Thijs Vande Vyvere, Fernanda Valerio, Zheng Ye, Krisztina Amrein, Konstantinos Kamnitsas, Haiyan Xu, Zhihui Yang and 11 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02210221 (Collaborative European NeuroTrauma Effectiveness Research in TBI), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02210221 completednot on this map

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Typeobservational_patient_registrySponsorUniversity Hospital, AntwerpRan2014 to 2021Enrolled4,559ConditionsTraumatic Brain Injury
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Impact of routine use of the GFAP and UCH-L1 TBI blood test for management of mild TBI on patient care in a European emergency department.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  3. Observational
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  6. Review
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
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  15. Concussion in Female Athletes of Contact Sports: A Scoping Review.Orthopaedic journal of sports medicine · 2024
    Article
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  19. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 5 countries.

Daniel P WhitehouseUniversity Division of Anaesthesia, Department of Medicine, University of Cambridge, UK.
Miguel MonteiroBiomedical Image Analysis Group, Department of Computing, Imperial College, London, UK.
Endre CzeiterDepartment of Neurosurgery, Medical School, University of Pécs, Rét u. 2, H-7623 Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group; Pécs, Hungary.
Thijs Vande VyvereResearch and Development, Icometrix, Leuven, Belgium; Department of Radiology, Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium.
Fernanda ValerioUniversity Division of Anaesthesia, Department of Medicine, University of Cambridge, UK.
Zheng YeUniversity Division of Anaesthesia, Department of Medicine, University of Cambridge, UK.
Krisztina AmreinDepartment of Neurosurgery, Medical School, University of Pécs, Rét u. 2, H-7623 Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
Konstantinos KamnitsasBiomedical Image Analysis Group, Department of Computing, Imperial College, London, UK.
Haiyan XuProgram for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, McKnight Brain Institute, L4-100L 1149 South Newell Drive, Gainesville, FL 32611, USA.
Zhihui YangProgram for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, McKnight Brain Institute, L4-100L 1149 South Newell Drive, Gainesville, FL 32611, USA.
Jan VerheydenResearch and Development, Icometrix, Leuven, Belgium.
Tilak DasDepartment of Radiology, Addenbrooke's Hospital, Cambridge, UK.
Evgenios N KornaropoulosUniversity Division of Anaesthesia, Department of Medicine, University of Cambridge, UK.
Ewout SteyerbergCenter for Medical Decision Making, Department of Public Health, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, Netherlands; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
Andrew I R MaasDepartment of Neurosurgery, Antwerp University Hospital and University of Antwerp, Wijlrijkstraat 10, 2650 Edegem, Belgium.
Kevin K W WangProgram for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, McKnight Brain Institute, L4-100L 1149 South Newell Drive, Gainesville, FL 32611, USA; Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Medical Center (VAMC), 1601 SW, Archer Rd. Gainesville FL 32608, USA.
András BükiDepartment of Neurosurgery, Medical School, University of Pécs, Rét u. 2, H-7623 Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
Ben GlockerBiomedical Image Analysis Group, Department of Computing, Imperial College, London, UK.
David K MenonUniversity Division of Anaesthesia, Department of Medicine, University of Cambridge, UK.
Virginia F J NewcombeUniversity Division of Anaesthesia, Department of Medicine, University of Cambridge, UK. Electronic address: vfjn2@cam.ac.uk.
CENTER-TBI Participants and Investigators
University of Cambridge · GBInstitute of Group Analysis · GBUniversity of Florida · USUniversity of Pecs · HUUniversity of Antwerp · BEAddenbrooke's Hospital · GBIcometrix (Belgium) · BELeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to understand the relationship between serum biomarker concentration and lesion type and volume found on computed tomography (CT) following all severities of TBI.

methodsConcentrations of six serum biomarkers (GFAP, NFL, NSE, S100B, t-tau and UCH-L1) were measured in samples obtained <24 hours post-injury from 2869 patients with all severities of TBI, enrolled in the CENTER-TBI prospective cohort study (NCT02210221). Imaging phenotypes were defined as intraparenchymal haemorrhage (IPH), oedema, subdural haematoma (SDH), extradural haematoma (EDH), traumatic subarachnoid haemorrhage (tSAH), diffuse axonal injury (DAI), and intraventricular haemorrhage (IVH). Multivariable polynomial regression was performed to examine the association between biomarker levels and both distinct lesion types and lesion volumes. Hierarchical clustering was used to explore imaging phenotypes; and principal component analysis and k-means clustering of acute biomarker concentrations to explore patterns of biomarker clustering.

findings2869 patient were included, 68% (n=1946) male with a median age of 49 years (range 2-96). All severities of TBI (mild, moderate and severe) were included for analysis with majority (n=1946, 68%) having a mild injury (GCS 13-15). Patients with severe diffuse injury (Marshall III/IV) showed significantly higher levels of all measured biomarkers, with the exception of NFL, than patients with focal mass lesions (Marshall grades V/VI). Patients with either DAI+IVH or SDH+IPH+tSAH, had significantly higher biomarker concentrations than patients with EDH. Higher biomarker concentrations were associated with greater volume of IPH (GFAP, S100B, t-tau;adj r2 range:0·48-0·49; p<0·05), oedema (GFAP, NFL, NSE, t-tau, UCH-L1;adj r2 range:0·44-0·44; p<0·01), IVH (S100B;adj r2 range:0.48-0.49; p<0.05), Unsupervised k-means biomarker clustering revealed two clusters explaining 83·9% of variance, with phenotyping characteristics related to clinical injury severity.

interpretationInterpretation: Biomarker concentration within 24 hours of TBI is primarily related to severity of injury and intracranial disease burden, rather than pathoanatomical type of injury.

fundingCENTER-TBI is funded by the European Union 7th Framework programme (EC grant 602150).

Indexed as

Brain Injuries, TraumaticProteomicsBiomarkersHumansMaleProspective StudiesTomography, X-Ray ComputedBiomarkersBiomarkersBrain injury, TraumaticComputed tomographyNeuroimaging

Identifiers

PMID34959133
PMCPMC8718895
OpenAlexW4200434432

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.