ArticleThe Journal of cell biology2022
Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.
Article in The Journal of cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Targeting ARF6-SUCNR1 Axis: Antisense Oligonucleotide Adjuvants for Neutrophil Immunometabolism.International journal of molecular sciences · 2026Review
- Fission yeast Pdk1 kinase regulates cytokinesis and eisosomes.Molecular biology of the cell · 2025Article
- Fission yeast Pdk1 kinase regulates cytokinesis and eisosomes.bioRxiv : the preprint server for biology · 2025Article
- Coupling Bacterial Cell Size Regulation with Clonal Proliferation Dynamics Reveals Cell Division Based on Surface Area.bioRxiv : the preprint server for biology · 2025Article
- A generalized adder for cell size homeostasis: Effects on stochastic clonal proliferation.Biophysical journal · 2025Article
- A GeneralizedbioRxiv : the preprint server for biology · 2024Article
- Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder.NPJ systems biology and applications · 2024Article
- Design principles of Cdr2 node patterns in fission yeast cells.Molecular biology of the cell · 2023Article
- The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time.Current biology : CB · 2023Article
- Design principles of Cdr2 node patterns in fission yeast cells.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Fission yeast cells prevent mitotic entry until a threshold cell surface area is reached. The protein kinase Cdr2 contributes to this size control system by forming multiprotein nodes that inhibit Wee1 at the medial cell cortex. Cdr2 node anchoring at the cell cortex is not fully understood. Through a genomic screen, we identified the conserved GTPase Arf6 as a component of Cdr2 signaling. Cells lacking Arf6 failed to divide at a threshold surface area and instead shifted to volume-based divisions at increased overall size. Arf6 stably localized to Cdr2 nodes in its GTP-bound but not GDP-bound state, and its guanine nucleotide exchange factor (GEF), Syt22, was required for both Arf6 node localization and proper size at division. In arf6Δ mutants, Cdr2 nodes detached from the membrane and exhibited increased dynamics. These defects were enhanced when arf6Δ was combined with other node mutants. Our work identifies a regulated anchor for Cdr2 nodes that is required for cells to sense surface area.
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