Evidence map›Paper›PMID 34958553›Full record

ArticleJournal of the American Society for Mass Spectrometry2022

Proteomic Analysis Reveals Low-Dose PARP Inhibitor-Induced Differential Protein Expression in BRCA1-Mutated High-Grade Serous Ovarian Cancer Cells.

Jesenia M Perez, Carly A I Twigg, Weihua Guan, Stefani N Thomas

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jesenia M PerezMicrobiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, United States.ORCID https://orcid.org/0000-0002-1566-530X
Carly A I TwiggDepartment of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, United States.
Weihua GuanDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis, Minnesota 55455, United States.
Stefani N ThomasDepartment of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, United States.ORCID https://orcid.org/0000-0003-1679-5453
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494NCI NIH HHS P30 CA077598
6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSOC) is the most common form of ovarian cancer diagnosed in patients worldwide. Patients with

Indexed as

Cell Line, TumorChromatography, High Pressure LiquidFemaleHumansIndazolesIndolesMass SpectrometryMitochondriaNeoplasm GradingOvarian NeoplasmsPiperidinesPoly(ADP-ribose) Polymerase InhibitorsProteomicsSignal TransductionIndazolesIndolesniraparibPiperidinesPoly(ADP-ribose) Polymerase Inhibitorsrucaparibmass spectrometryovarian cancerPARP inhibitor (PARPi)proteomicstandem mass tags (TMT)

Identifiers

PMID34958553
PMCPMC8824432
OpenAlexW4200444461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.