ArticleMagnetic resonance in medicine2022
Age-dependent cerebrospinal fluid-tissue water exchange detected by magnetization transfer indirect spin labeling MRI.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 18 citations in OpenAlex.
- Simultaneous measurement of water transport across the blood-brain and blood-CSF barrier in the human brain with arterial spin labeling MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Rapid Tissue-CSF Water Exchange in the Human Brain Revealed by Magnetization Transfer Indirect Spin Labeling.Magnetic resonance in medicine · 2026Article
- Post-stroke glymphatic and meningeal lymphatic dysfunction: mechanisms, imaging evidence, and translational challenges.Frontiers in stroke · 2026Review
- MRI-based surrogates of brain clearance in narcolepsy type 1.Journal of sleep research · 2025Article
- Quantification of TMagnetic resonance in medicine · 2023Article
- Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling.NeuroImage · 2022Article
- Non-invasive MRI of choroid plexus-cerebrospinal fluid water exchange using multi-TE FLAIR.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeA non-invasive magnetization transfer indirect spin labeling (MISL) MRI method is developed to quantify the water exchange between cerebrospinal fluid (CSF) and other tissues in the brain and to examine the age-dependence of water exchange.
methodIn the pulsed MISL, we implemented a short selective pulse followed by a post-labeling delay before an MRI acquisition with a long echo time; in the continuous MISL, a train of saturation pulses was applied. MISL signal (∆Z) was obtained by the subtraction of the label MRI at -3.5 ppm from the control MRI at 200 ppm. CSF was extracted from the mouse ventricles for the MISL optimization and validation. Comparison between wild type (WT) and aquaporin-4 knockout (AQP4
resultsThe pulsed MISL method observed that the MISL signal reached the maximum at 1.5 s. The continuous MISL method showed the highest MISL signal in the fourth ventricle (∆Z = 13.5% ± 1.4%), whereas the third ventricle and the lateral ventricles had similar MISL ∆Z values (∆Z = 12.0% ± 1.8%). Additionally, significantly lower ∆Z (9.3%-18.7% reduction) was found in all ventricles for the adult mice than those of the young mice (p < 0.02). For the AQP4
conclusionThe MISL method has a great potential to study CSF water exchange with the surrounding tissues in brain.
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