Evidence map›Paper›PMID 34958422›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Quantitative imaging biomarkers of immune-related adverse events in immune-checkpoint blockade-treated metastatic melanoma patients: a pilot study.

Nežka Hribernik, Daniel T Huff, Andrej Studen, Katarina Zevnik, Žan Klaneček, Hamid Emamekhoo, Katja Škalic, Robert Jeraj, Martina Reberšek

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06207747 (Quantitative Analysis of PET/CT Images of Immune Related Side Effects in Metastatic Melanoma Patients), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06207747 naunknown statusnot on this map

Quantitative Analysis of PET/CT Images of Immune Related Side Effects in Metastatic Melanoma Patients

TypeinterventionalSponsorInstitute of Oncology LjubljanaRan2020 to 2025Enrolled70ConditionsMelanoma, PET CTArmsadditional PET/CT at 4 weeks, analysing using quantative analysis
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  6. Early-time-pointRadiology and oncology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Immune-related [Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  11. Article
  12. Review
  13. Can physiologic colonic [European journal of nuclear medicine and molecular imaging · 2023
    Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nežka HribernikDepartment of Medical Oncology, Institute of Oncology Ljubljana, Zaloška 2, SI-1000, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0002-6468-9906
Daniel T HuffDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0001-9792-4119
Andrej StudenFaculty of Mathematics and Physics, University of Ljubljana, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0002-1254-9530
Katarina ZevnikDepartment of Nuclear Medicine, Institute of Oncology Ljubljana, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-5665-4837
Žan KlanečekFaculty of Mathematics and Physics, University of Ljubljana, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0003-3409-7771
Hamid EmamekhooUniversity of Wisconsin Carbone Cancer Centre, Madison, WI, USA.ORCID https://orcid.org/0000-0002-8506-8703
Katja ŠkalicDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Robert JerajDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0002-2192-2931
Martina ReberšekDepartment of Medical Oncology, Institute of Oncology Ljubljana, Zaloška 2, SI-1000, Ljubljana, Slovenia. mrebersek@onko-i.si.ORCID http://orcid.org/0000-0002-7025-8571
University of Ljubljana · SIUniversity of Wisconsin–Madison · USInstitute of Oncology Ljubljana · SI

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206
6 · The paper itself

Abstract

purposeTo develop quantitative molecular imaging biomarkers of immune-related adverse event (irAE) development in malignant melanoma (MM) patients receiving immune-checkpoint inhibitors (ICI) imaged with

methods

resultsA total of 31% (18/58) patients experienced irAE in the three target organs: bowel (n=6), lung (n=5), and thyroid (n=9). Optimal percentiles for identifying irAE were bowel (SUV

conclusionsIncreased

Indexed as

MelanomaNeoplasms, Second PrimaryBiomarkersCutaneous Malignant MelanomaFluorodeoxyglucose F18HumansImmune Checkpoint InhibitorsPilot ProjectsPositron-Emission TomographyPositron Emission Tomography Computed TomographyRetrospective StudiesSkin NeoplasmsBiomarkersFluorodeoxyglucose F18Immune Checkpoint Inhibitors18F-FDG PET/CTImmune-checkpoint inhibitorsImmune-related adverse effectsQuantitative imaging biomarkers

Identifiers

PMID34958422
PMCPMC9016045
OpenAlexW4225424766

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.