Evidence map›Paper›PMID 34958419›Full record

ReviewCurrent topics in microbiology and immunology2024

The Background, Role and Approach for Development of a Controlled Human Infection Model for Nontyphoidal Salmonella.

Calman A MacLennan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in microbiology and immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Virulence and antimicrobial resistance inFrontiers in microbiology · 2026
    Review
  3. Article
  4. Open forum infectious diseases · 2023
    Article
  5. The Challenge Non-TyphoidalWellcome open research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Calman A MacLennanJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK. calman.maclennan@ndm.ox.ac.uk.

Funding

Medical Research Council MR/P008852/1
6 · The paper itself

Abstract

Nontyphoidal Salmonella (NTS) is responsible for a major global burden of disease and economic loss, particularly in low- and middle-income countries. It is designated a priority pathogen by the WHO for vaccine development and, with new impetus from vaccine developers, the establishment of an NTS controlled human infection model (CHIM) is timely and valuable. The broadly dichotomous clinical presentations of diarrhoea and invasive disease, commonly bacteraemia, present significant challenges to the development of an NTS CHIM. Nevertheless, if successful, such a CHIM will be invaluable for understanding the pathogenesis of NTS disease, identifying correlates of protection and advancing candidate vaccines towards licensure. This article describes the background case for a CHIM for NTS, the role of such a CHIM and outlines a potential approach to its development.

Indexed as

Salmonella InfectionsAnimalsHumansSalmonellaSalmonella VaccinesVaccine DevelopmentSalmonella VaccinesCHIMCorrelates of protectionHuman challengeNontyphoidalPathogenesisSalmonellaVaccine

Identifiers

PMID34958419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.